IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus
about
Activation of interferon regulatory factor 5 by site specific phosphorylationLinking susceptibility genes and pathogenesis mechanisms using mouse models of systemic lupus erythematosusRole of type I interferons in the activation of autoreactive B cellsIRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosusBrief Report: IRF5 systemic lupus erythematosus risk haplotype is associated with asymptomatic serologic autoimmunity and progression to clinical autoimmunity in mothers of children with neonatal lupusType I interferon receptor deficiency prevents murine Sjogren's syndromeDistinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axisSpontaneous activation of RNA-sensing pathways in autoimmune disease.Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus.Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.Nucleic acid sensing receptors in systemic lupus erythematosus: development of novel DNA- and/or RNA-like analogues for treating lupus.Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunityRNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.Interferon regulatory factors in human lupus pathogenesisIRF5 deficiency ameliorates lupus but promotes atherosclerosis and metabolic dysfunction in a mouse model of lupus-associated atherosclerosisGenetic susceptibility to systemic lupus erythematosus in the genomic eraIRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine productionThe PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humansIfih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity.Historical overview of immunological tolerance.Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupusUnique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Phenotype and function of B cells and dendritic cells from interferon regulatory factor 5-deficient mice with and without a mutation in DOCK2.Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.Specific detection of interferon regulatory factor 5 (IRF5): A case of antibody inequality.Genetics of the type I interferon pathway in systemic lupus erythematosus.Regulatory and pathogenetic mechanisms of autoantibodies in SLE.Toll-like receptor driven B cell activation in the induction of systemic autoimmunity.New tools for classification and monitoring of autoimmune diseasesInterferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.Interferon regulatory factor 5 and autoimmune lupus.Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity.Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population.Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics.Reactivity profiles of broadly neutralizing anti-HIV-1 antibodies are distinct from those of pathogenic autoantibodies.Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus.Interferon regulatory factor 5 is critical for the development of lupus in MRL/lpr mice.A meta-analysis of the association of IRF5 polymorphism with systemic lupus erythematosus.Lupus nephritis progression in FcγRIIB-/-yaa mice is associated with early development of glomerular electron dense deposits and loss of renal DNase I in severe disease.
P2860
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P2860
IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@ast
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@en
type
label
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@ast
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@en
prefLabel
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@ast
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@en
P2093
P2860
P50
P356
P1476
IFN regulatory factor 5 is req ...... f systemic lupus erythematosus
@en
P2093
Amanda A Watkins
Ann Marshak-Rothstein
Chih Long Liu
Christophe Richez
Patricia Busto
Paul J Utz
Regina Cheung
Rocco J Richards
P2860
P304
P356
10.4049/JIMMUNOL.0901748
P407
P577
2009-12-09T00:00:00Z