mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor functionPositive allosteric modulators of metabotropic glutamate 2 receptors in schizophrenia treatmentEmerging approaches for treatment of schizophrenia: modulation of glutamatergic signalingBiased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR CurrentsThe metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in miceN-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.Exploration of allosteric agonism structure-activity relationships within an acetylene series of metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulators (PAMs): discovery of 5-((3-fluorophenyl)ethynyl)-N-(3-methyloxetan-3-yl)picolinGene networks associated with conditional fear in mice identified using a systems genetics approach.Allosteric modulation of metabotropic glutamate receptors.Advancing drug discovery for schizophrenia.Targeting glutamate synapses in schizophreniaDiscovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity.Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughput Screening.Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.Imaging glutamate in schizophrenia: review of findings and implications for drug discovery.mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndromeTargeting metabotropic glutamate receptors for novel treatments of schizophrenia.Enhancement of extinction learning attenuates ethanol-seeking behavior and alters plasticity in the prefrontal cortex.Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.The NMDA receptor as a target for cognitive enhancementDevelopment of allosteric modulators of GPCRs for treatment of CNS disordersOpportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders.Group I and group II metabotropic glutamate receptor allosteric modulators as novel potential antipsychotics.Molecular Insights into Metabotropic Glutamate Receptor Allosteric ModulationFunctional interaction of mGlu5 and NMDA receptors in aversive learning in rats.Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats.Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample taskGlutamatergic targets for enhancing extinction learning in drug addictionCB1 augments mGluR5 function in medial prefrontal cortical neurons to inhibit amygdala hyperactivity in an arthritis pain model.Cognitive enhancers for facilitating drug cue extinction: insights from animal models.The role of the tripartite glutamatergic synapse in the pathophysiology of Alzheimer's disease.Functional impact of allosteric agonist activity of selective positive allosteric modulators of metabotropic glutamate receptor subtype 5 in regulating central nervous system function.Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in RatsmGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal Cortex
P2860
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P2860
mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@ast
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@en
type
label
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@ast
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@en
prefLabel
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@ast
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@en
P2093
P2860
P356
P1476
mGluR5 positive allosteric mod ...... D and enhance spatial learning
@en
P2093
Alexandra N Telk
Douglas J Sheffler
Jennifer E Ayala
Jessica L Banko
M Foster Olive
Noreen L Watson
Paulianda J Jones
Richard Williams
Yelin Chen
Yongqin Zhang
P2860
P2888
P304
P356
10.1038/NPP.2009.30
P407
P577
2009-03-18T00:00:00Z
P5875
P6179
1025854513