Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction
about
STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expressionHrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growthHierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activationSTAM2, a new member of the STAM family, binding to the Janus kinasesRedundant promoter elements mediate IL-3-induced expression of a novel cytokine-inducible gene, cyclonDistinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversityPyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathwayThe B cell antigen receptor and overexpression of MYC can cooperate in the genesis of B cell lymphomasA critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-MycJanus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.Latent membrane protein 1 of Epstein-Barr virus interacts with JAK3 and activates STAT proteinsProlactin receptor signal transduction.Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit.Cytokine-induced survival of activated T cells in vitro and in vivoRequirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.The amino terminus of JAK3 is necessary and sufficient for binding to the common gamma chain and confers the ability to transmit interleukin 2-mediated signals.In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.Expression of the c-myc proto-oncogene is essential for HIV-1 infection in activated T cells.Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.Recent patents in the discovery of small molecule inhibitors of JAK3.JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia.A permissive role for phosphatidylinositol 3-kinase in the Stat5-mediated expression of cyclin D2 by the interleukin-2 receptor.Anti-apoptotic signaling by the interleukin-2 receptor reveals a function for cytoplasmic tyrosine residues within the common gamma (gamma c) receptor subunit.Regulation of c-myc transcription by interleukin-2 (IL-2). Identification of a novel IL-2 response element interacting with STAT-4.Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinerySTAT3 is required for the gp130-mediated full activation of the c-myc gene.Attenuation of Interleukin 2 Signal in the Spleen Cells of Complex Ganglioside-lacking MiceSignal TransductionThrough Cytokine Receptors
P2860
Q24305820-EEFF7F23-F86D-4D84-96DC-4462571D45A4Q24315648-C5FCA317-7AC8-41DF-9366-86AAC4E8ED71Q28115484-39215B0A-A9B2-40A0-8DAA-35C07E6BC02DQ28141037-6D49792A-726B-4771-BEE0-524CC058ADA9Q28508756-F7BF19B4-095F-422E-AE5D-E4BF048A875CQ28609039-DD7811F9-2862-4586-83F1-BF7A2634E13AQ28610859-CF2B1C74-24D4-4C26-A3C3-98955D488578Q33346593-58BB1885-61FB-46A2-BF47-4D4C328CB7B8Q33774162-1698D8DD-C1AF-4AFA-8650-D043CBECD8B1Q33888375-A5F8FE86-BB21-47A6-B36D-8C4A5117ECBFQ33891012-2E5DD271-1CC8-4B9F-9E73-979881BB58F3Q34447963-60A6CEB8-FBF9-4E4A-9FB0-9B884C70DD1CQ35907478-75051B7C-A8FE-4D32-BE7B-346833617471Q36010639-D64FB31A-7B75-4C88-9EFD-0FDE584AA794Q36026082-C6C67616-D758-4ACD-AE4D-BF0C2D4FD3C8Q36242620-71E62617-4234-463B-8688-271F17B42D0DQ36366827-D67A3990-1CA1-4B7A-B466-DBE0D3D2D77BQ36368186-6099C36E-A37C-4DAC-B217-0809B7A88112Q37250038-BB1E0313-AB43-4FE0-B567-940687FC5427Q37733546-5C78713E-C35F-4D15-9519-D21DC924D86AQ37808703-BF5E0779-1323-4209-8EA5-6CA7E9D57134Q38518751-54F8E6E4-AC9B-49E5-AF75-58D3D8DDB43BQ40678150-4C655005-77A3-4947-A98E-2B9DBF21741AQ40897143-0ADEC0A5-3537-460E-9772-A9FB39AE5500Q40971179-92491F8F-6220-459E-8FC7-84E51ECD1A1DQ42753357-1B9B5F90-4DA5-48BE-9508-3A76A77CD9FDQ57539148-78CA717A-0869-4DDC-BFB9-FEEFC689319DQ58173667-C72A17F2-D12C-4102-9AA4-9FFEC98F8C8F
P2860
Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction
description
1995 nî lūn-bûn
@nan
1995 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Critical role of the interleuk ...... but not bcl-2, gene induction
@ast
Critical role of the interleuk ...... but not bcl-2, gene induction
@en
type
label
Critical role of the interleuk ...... but not bcl-2, gene induction
@ast
Critical role of the interleuk ...... but not bcl-2, gene induction
@en
prefLabel
Critical role of the interleuk ...... but not bcl-2, gene induction
@ast
Critical role of the interleuk ...... but not bcl-2, gene induction
@en
P2093
P2860
P356
P1476
Critical role of the interleuk ...... but not bcl-2, gene induction
@en
P2093
P2860
P304
P356
10.1073/PNAS.92.19.8724
P407
P577
1995-09-01T00:00:00Z