The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy. - sprookjes - yvandenbroek - TriplyDB

The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.

The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.

http://www.wikidata.org/entity/Q33932723

about

Local amplification of glucocorticoids in the aging brain and impaired spatial memory Addressing unmet medical needs in type 2 diabetes: a narrative review of drugs under development Adipose tissue and adrenal glands: novel pathophysiological mechanisms and clinical applications Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD-1)Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization 11beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes.Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?Discovery of 2-Alkyl-1-arylsulfonylprolinamides as 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Novel and emerging diabetes mellitus drug therapies for the type 2 diabetes patient 11β-HSD1 is the major regulator of the tissue-specific effects of circulating glucocorticoid excess Discovery of Novel Insulin Sensitizers: Promising Approaches and Targets.11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice.Current therapies and emerging drugs in the pipeline for type 2 diabetes.A novel 11β-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits.Regulation of lipogenesis by glucocorticoids and insulin in human adipose tissue.Multiple epidural steroid injections and body mass index linked with occurrence of epidural lipomatosis: a case series.A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease.11β-Hydroxysteroid dehydrogenase type 1: relevance of its modulation in the pathophysiology of obesity, the metabolic syndrome and type 2 diabetes mellitus.Recycling between cortisol and cortisone in human splanchnic, subcutaneous adipose, and skeletal muscle tissues in vivo.Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.Effects of acute glucocorticoid blockade on metabolic dysfunction in patients with Type 2 diabetes with and without fatty liver 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors still improve metabolic phenotype in male 11β-HSD1 knockout mice suggesting off-target mechanisms.BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice Effects of antisense-mediated inhibition of 11β-hydroxysteroid dehydrogenase type 1 on hepatic lipid metabolism 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors Adamantyl ethanone pyridyl derivatives: potent and selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 Antisense reduction of 11β-hydroxysteroid dehydrogenase type 1 enhances energy expenditure and insulin sensitivity independent of food intake in C57BL/6J mice on a Western-type diet Cortisol dysregulation in obesity-related metabolic disorders.Effects of caloric restriction and low glycemic index diets associated with metformin on glucose metabolism and cortisol response in overweight/obese subjects: a case series study.Glucocorticoid-induced osteoporosis - a disorder of mesenchymal stromal cells?The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats Continuous inhibition of 11β-hydroxysteroid dehydrogenase type I in adipose tissue leads to tachyphylaxis in humans and rats but not in mice.Visceral adipose tissue: emerging role of gluco- and mineralocorticoid hormones in the setting of cardiometabolic alterations Lack of significant metabolic abnormalities in mice with liver-specific disruption of 11β-hydroxysteroid dehydrogenase type 1.CIDeR: multifactorial interaction networks in human diseases.The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity Adamantyl carboxamides and acetamides as potent human 11β-hydroxysteroid dehydrogenase type 1 inhibitors.The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity.

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The 11-beta-hydroxysteroid dehydrogenase type 1 inhibitor INCB13739 improves hyperglycemia in patients with type 2 diabetes inadequately controlled by metformin monotherapy.

http://www.wikidata.org/entity/Q33932723

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2010 nî lūn-bûn

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2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2010 թվականի ապրիլին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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The 11-beta-hydroxysteroid deh ...... lled by metformin monotherapy.

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The 11-beta-hydroxysteroid deh ...... lled by metformin monotherapy.

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Gregory Hollis

http://www.w3.org/2001/XMLSchema#string

INCB13739-202 Principal Investigators

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Jonathan R Seckl

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Reid Huber

http://www.w3.org/2001/XMLSchema#string

Richard Levy

http://www.w3.org/2001/XMLSchema#string

Robert Flores

http://www.w3.org/2001/XMLSchema#string

Salomon Banarer

http://www.w3.org/2001/XMLSchema#string

Silvio E Inzucchi

http://www.w3.org/2001/XMLSchema#string

Vivian A Fonseca

http://www.w3.org/2001/XMLSchema#string

Wenqing Yao

http://www.w3.org/2001/XMLSchema#string

P2860

Minireview: 11beta-hydroxysteroid dehydrogenase type 1- a tissue-specific amplifier of glucocorticoid action

Correlation between the administered dose of DHEA and serum levels of DHEA and DHEA-S in human volunteers: analysis of published data.

Tissue-specific dysregulation of cortisol metabolism in human obesity.

11 beta-Hydroxysteroid dehydrogenase.

Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity

A transgenic model of visceral obesity and the metabolic syndrome.

Effect of thiazolidinediones on body weight in patients with diabetes mellitus.

Promoting effect of glucocorticoids on the differentiation of human adipocyte precursor cells cultured in a chemically defined medium.

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice.

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice.

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1516-1522

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10.2337/DC09-2315

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7

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33

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Julio Rosenstock

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43299124

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20413513

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type-1 diabetes

type-2 diabetes

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2890352

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