Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas - sprookjes - yvandenbroek - TriplyDB

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

http://www.wikidata.org/entity/Q34063705

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Mutational profiling of kinases in glioblastoma.Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Aspects of coverage in medical DNA sequencing Targeting RTK Signaling Pathways in Cancer Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers Will kinase inhibitors make it as glioblastoma drugs?A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours Novel insight into mutational landscape of head and neck squamous cell carcinoma Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.Novel computational methods for increasing PCR primer design effectiveness in directed sequencing IGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting.Computational tools for the interactive exploration of proteomic and structural data.Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas.PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Targeting the PDGF signaling pathway in tumor treatment DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors.Our changing view of the genomic landscape of cancer.FGFR2 gene amplification and clinicopathological features in gastric cancer Deciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer Therapy Prevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas.Subtyping of gliomas of various WHO grades by the application of immunohistochemistry.Statistical challenges with gene expression studies.High-throughput mutational analysis of the human cancer genome.Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis.Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas.Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.The FGF family: biology, pathophysiology and therapy Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects.Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.Anosmin-1 contributes to brain tumor malignancy through integrin signal pathways.Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes.Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.

P2860

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P2860

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

http://www.wikidata.org/entity/Q34063705

description

2005 nî lūn-bûn

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2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@ast

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@en

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@nl

type

label

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@ast

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@en

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@nl

prefLabel

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@ast

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@en

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@nl

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PNAS.0507200102

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

@en

P2093

Alexia Tsiamouri

http://www.w3.org/2001/XMLSchema#string

Andrew J G Simpson

http://www.w3.org/2001/XMLSchema#string

Dana Busam

http://www.w3.org/2001/XMLSchema#string

Gregory J Riggins

http://www.w3.org/2001/XMLSchema#string

Jennifer B Edwards

http://www.w3.org/2001/XMLSchema#string

Jiaqi Huang

http://www.w3.org/2001/XMLSchema#string

Karen Beeson

http://www.w3.org/2001/XMLSchema#string

Kathleen M Murphy

http://www.w3.org/2001/XMLSchema#string

Kelvin Li

http://www.w3.org/2001/XMLSchema#string

Oleksandr Buzko

http://www.w3.org/2001/XMLSchema#string

P2860

Mechanism of action and in vivo role of platelet-derived growth factor

Digital karyotyping

Cellular signaling by fibroblast growth factor receptors

The protein kinase complement of the human genome

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients

PROCHECK: a program to check the stereochemical quality of protein structures

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib.

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14344-14349

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scholarly article

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10.1073/PNAS.0507200102

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40

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102

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J. Craig Venter

Charles G Eberhart

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2005-09-26T00:00:00Z

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7576981

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16186508

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1242336

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