Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
about
Mutational profiling of kinases in glioblastoma.Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cellsIntegrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Aspects of coverage in medical DNA sequencingTargeting RTK Signaling Pathways in CancerFunctional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancersWill kinase inhibitors make it as glioblastoma drugs?A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine KinasesEpidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domainMolecular mechanisms of fibroblast growth factor signaling in physiology and pathologyEmergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumoursNovel insight into mutational landscape of head and neck squamous cell carcinomaIdentification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models.Novel computational methods for increasing PCR primer design effectiveness in directed sequencingIGF2 over-expression in solitary fibrous tumours is independent of anatomical location and is related to loss of imprinting.Computational tools for the interactive exploration of proteomic and structural data.Clinical association analysis of ependymomas and pilocytic astrocytomas reveals elevated FGFR3 and FGFR1 expression in aggressive ependymomas.PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.Targeting the PDGF signaling pathway in tumor treatmentDFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors.Our changing view of the genomic landscape of cancer.FGFR2 gene amplification and clinicopathological features in gastric cancerDeciphering the Key Features of Malignant Tumor Microenvironment for Anti-cancer TherapyPrevalence, clinico-pathological value, and co-occurrence of PDGFRA abnormalities in diffuse gliomas.Subtyping of gliomas of various WHO grades by the application of immunohistochemistry.Statistical challenges with gene expression studies.High-throughput mutational analysis of the human cancer genome.Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis.Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy.Recurrent Mutations of Chromatin-Remodeling Genes and Kinase Receptors in Pheochromocytomas and Paragangliomas.Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.The FGF family: biology, pathophysiology and therapyWhole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects.Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations.Anosmin-1 contributes to brain tumor malignancy through integrin signal pathways.Expression profiling of the ovarian surface kinome reveals candidate genes for early neoplastic changes.Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
P2860
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P2860
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@ast
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@en
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@nl
type
label
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@ast
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@en
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@nl
prefLabel
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@ast
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@en
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@nl
P2093
P2860
P356
P1476
Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas
@en
P2093
Alexia Tsiamouri
Andrew J G Simpson
Dana Busam
Gregory J Riggins
Jennifer B Edwards
Jiaqi Huang
Karen Beeson
Kathleen M Murphy
Oleksandr Buzko
P2860
P304
14344-14349
P356
10.1073/PNAS.0507200102
P407
P577
2005-09-26T00:00:00Z