Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
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Perlecan controls neurogenesis in the developing telencephalonIndian hedgehog mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levelsItraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonistsFunctional analysis of mutations in TGIF associated with holoprosencephaly.Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseasesItraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growthA sonic hedgehog missense mutation associated with holoprosencephaly causes defective binding to GAS1Holoprosencephaly.Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.The molecular genetics of holoprosencephaly.A novel proteolytic event controls Hedgehog intracellular sorting and distribution to receptive fieldsCleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implicationsA genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila.Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition.Sonic hedgehog signaling in the lung. From development to disease.Processing and turnover of the Hedgehog protein in the endoplasmic reticulum.New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish.Signaling domain of Sonic Hedgehog as cannibalistic calcium-regulated zinc-peptidaseZinc inhibits Hedgehog autoprocessing: linking zinc deficiency with Hedgehog activationFörster resonance energy transfer-based cholesterolysis assay identifies a novel hedgehog inhibitor.Berberine, a natural compound, suppresses Hedgehog signaling pathway activity and cancer growth.Inhibition of Hedgehog-Signaling Driven Genes in Prostate Cancer Cells by Sutherlandia frutescens Extract.Hedgehog secretion and signal transduction in vertebrates.Ethanol-induced microphthalmia is not mediated by changes in retinoic acid or sonic hedgehog signaling during retinal neurogenesisActivation of the hedgehog signaling pathway in the developing lens stimulates ectopic FoxE3 expression and disruption in fiber cell differentiation.Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.Developmental mechanisms and experimental models to understand forebrain malformative diseases.The role of ciliary trafficking in Hedgehog receptor signaling.Posaconazole, a Second-Generation Triazole Antifungal Drug, Inhibits the Hedgehog Signaling Pathway and Progression of Basal Cell Carcinoma.Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes.The mutational spectrum of holoprosencephaly-associated changes within the SHH gene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis.Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans.Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer.Interactions between Hedgehog proteins and their binding partners come into view.Palmitoylation of Hedgehog proteins.Smoothened antagonists: a promising new class of antitumor agents.Novel insights into the development and maintenance of the blood-brain barrier.Morphogen transport: theoretical and experimental controversies.Development of the Vertebrate Eye and Retina.
P2860
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P2860
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@ast
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@en
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@nl
type
label
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@ast
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@en
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@nl
prefLabel
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@ast
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@en
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly.
@nl
P2860
P356
P1476
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
@en
P2093
Philip A Beachy
Tapan Maity
P2860
P304
17026-17031
P356
10.1073/PNAS.0507848102
P407
P50
P577
2005-11-10T00:00:00Z