Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
about
Genetic determinants and potential therapeutic targets for pancreatic adenocarcinomaPediatric medulloblastoma - update on molecular classification driving targeted therapiesTamoxifen Resistance: Emerging Molecular TargetsDisruption of Vitamin D and Calcium Signaling in Keratinocytes Predisposes to Skin CancerStructure and dynamics of molecular networks: a novel paradigm of drug discovery: a comprehensive reviewRegulation of extracellular signal-regulated kinase 1/2 influences hippocampal neuronal survival in a rat model of diabetic cerebral ischemiaContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyHypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cellsHedgehog/Gli promotes epithelial-mesenchymal transition in lung squamous cell carcinomas.Aspirin inhibits the SHH/GLI1 signaling pathway and sensitizes malignant glioma cells to temozolomide therapy.Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.Concomitant targeting of EGF receptor, TGF-beta and SRC points to a novel therapeutic approach in pancreatic cancer.Sonic hedgehog pathway expression in non-small cell lung cancerA new role for Hedgehogs in juxtacrine signaling.Gli as a novel therapeutic target in malignant pleural mesotheliomaSynergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1Thyroid-specific transcription factors and their roles in thyroid cancer.Regulation of sonic hedgehog expression by integrin β1 and epidermal growth factor receptor in intestinal epitheliumFrequent gene products and molecular pathways altered in prostate cancer- and metastasis-initiating cells and their progenies and novel promising multitargeted therapies.Pathway profiling and rational trial design for studies in advanced stage cervical carcinoma: a review and a perspective.Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer.Silibinin and its 2,3-dehydro-derivative inhibit basal cell carcinoma growth via suppression of mitogenic signaling and transcription factors activation.Dynamic Bayesian Network Modeling of the Interplay between EGFR and Hedgehog Signaling.Drug resistance and its significance for treatment decisions in non-small-cell lung cancer.Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Oxidative stress contributes to the impaired sonic hedgehog pathway in type 1 diabetic mice with myocardial infarction.Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein.Marked improvement of cytotoxic effects induced by docetaxel on highly metastatic and androgen-independent prostate cancer cells by downregulating macrophage inhibitory cytokine-1.Metformin increases antitumor activity of MEK inhibitors through GLI1 downregulation in LKB1 positive human NSCLC cancer cells.Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells.Epigenetic deregulation of the anaplastic lymphoma kinase gene modulates mesenchymal characteristics of oral squamous cell carcinomasConstitutive activation of smoothened leads to impaired developments of postnatal bone in mice.Altered gene products involved in the malignant reprogramming of cancer stem/progenitor cells and multitargeted therapies.Gli promotes epithelial-mesenchymal transition in human lung adenocarcinomasEGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth.Therapeutic targets associated to E-cadherin dysfunction in gastric cancer.Vitamin D receptor, a tumor suppressor in skin.EZH2-mediated upregulation of ROS1 oncogene promotes oral cancer metastasis.Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells.Next generation of network medicine: interdisciplinary signaling approaches.
P2860
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P2860
Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Frequent deregulations in the ...... ession and targeted therapies.
@ast
Frequent deregulations in the ...... ession and targeted therapies.
@en
Frequent deregulations in the ...... ession and targeted therapies.
@nl
type
label
Frequent deregulations in the ...... ession and targeted therapies.
@ast
Frequent deregulations in the ...... ession and targeted therapies.
@en
Frequent deregulations in the ...... ession and targeted therapies.
@nl
prefLabel
Frequent deregulations in the ...... ession and targeted therapies.
@ast
Frequent deregulations in the ...... ession and targeted therapies.
@en
Frequent deregulations in the ...... ession and targeted therapies.
@nl
P2860
P356
P1476
Frequent deregulations in the ...... ession and targeted therapies.
@en
P2093
Murielle Mimeault
Surinder K Batra
P2860
P304
P356
10.1124/PR.109.002329
P577
2010-09-01T00:00:00Z