Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models. - sprookjes - yvandenbroek - TriplyDB

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models.

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models.

http://www.wikidata.org/entity/Q34140014

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Animal models for the study of HCV Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees Chimeric mouse model for the infection of hepatitis B and C viruses Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies Canine hepacivirus is not associated with chronic liver disease in dogs.Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus.Hepatitis C homolog in dogs with respiratory illness Griffithsin has antiviral activity against hepatitis C virus Monoclonal antibodies against extracellular domains of claudin-1 block hepatitis C virus infection in a mouse model.Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo.Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant.Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A.Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.A novel hepacivirus with an unusually long and intrinsically disordered NS5A protein in a wild Old World primate.Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.Hepatitis C virus infection and related liver disease: the quest for the best animal model Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.Broadening CD4+ and CD8+ T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes.Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors.Hepatitis C Virus Postexposure Prophylaxis in the Healthcare Worker: Why Direct-Acting Antivirals Don't Change a Thing.Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice.Persistent human hepatitis B virus infection in cynomolgus monkeys: a novel animal model in the search for a cure?Thermostability of seven hepatitis C virus genotypes in vitro and in vivo.The Chimpanzee Model of Viral Hepatitis: Advances in Understanding the Immune Response and Treatment of Viral Hepatitis.Animal Models to Study Hepatitis C Virus Infection.Emerging animal viruses: real threats or simple bystanders?

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Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models.

http://www.wikidata.org/entity/Q34140014

description

2010 nî lūn-bûn

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2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2010 թվականի մայիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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The Journal of Infectious Diseases

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Challenge pools of hepatitis C ...... n liver-chimeric mouse models.

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Gerald Eder

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Krzysztof Krawczynski

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Raymond Tellier

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Robert H Purcell

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Roger H Miller

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Ronald E Engle

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Stephen M Feinstone

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Sugantha Govindarajan

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William C Satterfield

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P2860

Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes

Viral persistence, antibody to E1 and E2, and hypervariable region 1 sequence stability in hepatitis C virus-inoculated chimpanzees.

Analysis of hepatitis C virus-inoculated chimpanzees reveals unexpected clinical profiles.

Hepatitis C Virus Subtyping by a Core-Envelope 1-Based Reverse Transcriptase PCR Assay with Sequencing and Its Use in Determining Subtype Distribution among Danish Patients

Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

In Vivo Study of the HC-TN Strain of Hepatitis C Virus Recovered from a Patient with Fulminant Hepatitis: RNA Transcripts of a Molecular Clone (pHC-TN) Are Infectious in Chimpanzees but Not in Huh7.5 Cells

Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

Previously Infected Chimpanzees Are Not Consistently Protected against Reinfection or Persistent Infection after Reexposure to the Identical Hepatitis C Virus Strain

Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA

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10.1086/651579

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9

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Raymond Tellier

Philip Meuleman

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