Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase - sprookjes - yvandenbroek - TriplyDB

Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase

Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase

http://www.wikidata.org/entity/Q34162782

about

Substance P enhances microglial density in the substantia nigra through neurokinin-1 receptor/NADPH oxidase-mediated chemotaxis in mice A novel role of microglial NADPH oxidase in mediating extra-synaptic function of norepinephrine in regulating brain immune homeostasis.Post-treatment with an ultra-low dose of NADPH oxidase inhibitor diphenyleneiodonium attenuates disease progression in multiple Parkinson's disease models Apocynin prevents mitochondrial burdens, microglial activation, and pro-apoptosis induced by a toxic dose of methamphetamine in the striatum of mice via inhibition of p47phox activation by ERK Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons.NADPH oxidase in brain injury and neurodegenerative disorders NADPH oxidase-derived H2O2 mediates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's disease.Prolyl oligopeptidase and dipeptidyl peptidase II/dipeptidyl peptidase IV ratio in the cerebrospinal fluid in Parkinson's disease: historical overview and future prospects.Neuropeptides and Microglial Activation in Inflammation, Pain, and Neurodegenerative Diseases Brain and Peripheral Atypical Inflammatory Mediators Potentiate Neuroinflammation and Neurodegeneration.Complement receptor 3 mediates NADPH oxidase activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway.Mast cells in the brain - Old cells, new target.Sulforaphane Ameliorates 3-Nitropropionic Acid-Induced Striatal Toxicity by Activating the Keap1-Nrf2-ARE Pathway and Inhibiting the MAPKs and NF-κB Pathways.Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway.2,5-Hexanedione induces dopaminergic neurodegeneration through integrin αMβ2/NADPH oxidase axis-mediated microglial activation.Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization.Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor.Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models.

P2860

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P2860

Substance P exacerbates dopaminergic neurodegeneration through neurokinin-1 receptor-independent activation of microglial NADPH oxidase

http://www.wikidata.org/entity/Q34162782

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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type

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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JNEUROSCI.2238-14.2014

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Journal of Neuroscience

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Substance P exacerbates dopami ...... on of microglial NADPH oxidase

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Belinda Wilson

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Bonnie Robinson

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Chun-Hsien Chu

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Esteban Oyarzabal

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Hyoung-Chun Kim

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Li Qian

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Shih-Heng Chen

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Syed Ali

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P2860

Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Differential activation of intracellular effector by two isoforms of human neurokinin-1 receptor

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

Endogenous dynorphin protects against neurotoxin-elicited nigrostriatal dopaminergic neuron damage and motor deficits in mice

Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.

Reactive microgliosis: extracellular micro-calpain and microglia-mediated dopaminergic neurotoxicity.

Treatment with a substance P receptor antagonist is neuroprotective in the intrastriatal 6-hydroxydopamine model of early Parkinson's disease

Neuroprotective effect of dextromethorphan in the MPTP Parkinson's disease model: role of NADPH oxidase.

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12490-12503

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37

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Jau-Shyong Hong

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25209287

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