Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
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Heparanase enhances the generation of activated factor X in the presence of tissue factor and activated factor VIIHSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.Heparin: Past, Present, and FutureGlycoconjugates and related molecules in human vascular endothelial cellsInvolvement of heparanase in atherosclerosis and other vessel wall pathologiesNewly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinasesHeparanase induces Akt phosphorylation via a lipid raft receptorIL-1 is required for tumor invasiveness and angiogenesisHeparan sulfate signaling in cancerPositive association of heparanase expression with tumor invasion and lymphatic metastasis in gastric carcinoma.Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1.Development and NMR validation of minimal pharmacophore hypotheses for the generation of fragment libraries enriched in heparanase inhibitors.Small RNA interference-mediated gene silencing of heparanase abolishes the invasion, metastasis and angiogenesis of gastric cancer cellsHeparanase promotes engraftment and prevents graft versus host disease in stem cell transplantationHeparanase and hepatocellular carcinoma: promoter or inhibitor?Expression of heparanase in soft tissue sarcomas of adults.Regulation of intracellular signaling by extracellular glycan remodeling.Modification of heparanase gene expression in response to conditioning and LPS treatment: strong correlation to rs4693608 SNP.Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donorsA novel human heparanase splice variant, T5, endowed with protumorigenic characteristics.In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosisUnraveling the specificity of heparanase utilizing synthetic substrates.Six blind men and the elephant--the many faces of heparan sulfate.Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats.The Quantification of Glycosaminoglycans: A Comparison of HPLC, Carbazole, and Alcian Blue Methods.CXCL7-Mediated Stimulation of Lymphangiogenic Factors VEGF-C, VEGF-D in Human Breast Cancer CellsGlycosaminoglycans in Human and Bovine Serum: Detection of Twenty-Four Heparan Sulfate and Chondroitin Sulfate Motifs Including a Novel Sialic Acid-modified Chondroitin Sulfate Linkage HexasaccharideHeparanase cooperates with Ras to drive breast and skin tumorigenesisAdaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant.Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasisSmall RNAs targeting transcription start site induce heparanase silencing through interference with transcription initiation in human cancer cellsHeparin and liver heparan sulfate can rescue hepatoma cells from topotecan action.Dissociation between mature phenotype and impaired transmigration in dendritic cells from heparanase-deficient mice.Heparanase promotes human gastric cancer cells migration and invasion by increasing Src and p38 phosphorylation expression.Processing of heparanase is mediated by syndecan-1 cytoplasmic domain and involves syntenin and α-actinin.The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis.Prognostic value of heparanase expression and cellular localization in oral cancer.Heparanase and coagulation-new insights.Heparanase is a host enzyme required for herpes simplex virus-1 release from cells.Clinical significance of heparanase splice variant (t5) in renal cell carcinoma: evaluation by a novel t5-specific monoclonal antibody
P2860
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P2860
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
description
2001 nî lūn-bûn
@nan
2001 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@ast
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@en
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@nl
type
label
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@ast
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@en
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@nl
prefLabel
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@ast
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@en
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@nl
P2860
P356
P1476
Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
@en
P2093
I Vlodavsky
Y Friedmann
P2860
P304
P356
10.1172/JCI13662
P407
P577
2001-08-01T00:00:00Z