Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.
about
T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformationStructural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC DiscriminationStructural Model of the Extracellular Assembly of the TCR-CD3 Complex.Somatic hypermutation maintains antibody thermodynamic stability during affinity maturationT Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational RearrangementsStructure of the Chicken CD3 / Heterodimer and Its Assembly with the T Cell ReceptorNovel serial positive enrichment technology enables clinical multiparameter cell sortingHigh-resolution imaging of the immunological synapse and T-cell receptor microclustering through microfabricated substrates.The SCHOOL of nature: I. Transmembrane signaling.Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.Highly enhanced cytotoxicity of a dimeric bispecific diabody, the hEx3 tetrabody.Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors.Piecing together the family portrait of TCR-CD3 complexes.Molecular architecture of the αβ T cell receptor-CD3 complex.A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor.Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.Symmetry breaking: bispecific antibodies, the beginnings, and 50 years onComputational Identification of Antibody Epitopes on the Dengue Virus NS1 Protein.Mechanistic basis of immunotherapies for type 1 diabetes mellitusThe quality of chimpanzee T-cell activation and simian immunodeficiency virus/human immunodeficiency virus susceptibility achieved via antibody-mediated T-cell receptor/CD3 stimulation is a function of the anti-CD3 antibody isotype.A conserved αβ transmembrane interface forms the core of a compact T-cell receptor-CD3 structure within the membrane.The alphabeta T cell receptor is an anisotropic mechanosensor.Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.Positive selection on apoptosis related genes.Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.A view into the blind spot: solution NMR provides new insights into signal transduction across the lipid bilayer.TCR Nanoclusters as the Framework for Transmission of Conformational Changes and Cooperativity.A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned.The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function.Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen ReceptorsA specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway.A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens.Allosteric changes in the TCR/CD3 structure upon interaction with extra- or intra-cellular ligands.Loss of N-terminal charged residues of mouse CD3 epsilon chains generates isoforms modulating antigen T cell receptor-mediated signals and T cell receptor-CD3 interactions.Polymorphisms of CD3epsilon in cynomolgus and rhesus monkeys and their relevance to anti-CD3 antibodies and immunotoxins.Interactions between CD8alphabeta and the TCRalphabeta/CD3-receptor complex.The Affinity of Elongated Membrane-Tethered Ligands Determines Potency of T Cell Receptor Triggering.CalQuo 2 : Automated Fourier-space, population-level quantification of global intracellular calcium responses.TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling.Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells.
P2860
Q24321347-03A46B62-BB3E-4555-85BE-858D004EF489Q26782908-9B87A9DE-116B-469D-A64A-A63ECF1F2AD4Q27319571-86AEA5D3-68A8-4470-AE6E-B8DC62F052C2Q27676628-B422ECBC-5DB9-4A1D-9776-104E5F0225CDQ27676807-3E571A75-C3C1-4ED9-A60A-B3A91BE41443Q27681566-EFD3541A-9C97-471D-949B-1F72E3D2F380Q28730418-CBCF94FC-3BAB-42BF-B1C5-72FA9697C056Q30503844-8E470274-3F46-4CB9-AA2E-813494BD3035Q33351190-109E5BBE-8E15-404C-90AA-AB538335F28DQ33752200-1529DA3C-6754-4E73-AAAC-1EBD8A281344Q33966998-5CA52FCD-8E18-4105-B233-02D6F1F9C2ECQ34113293-ABF27DB8-474F-48AF-914D-FCE0A02E7F00Q34643623-257F62F3-D4E6-48F2-9F8A-3A9004C6F87AQ34708948-2B265D09-6704-4ED6-8D0A-B6E26EFCCEA5Q35891753-04C55303-7E47-4A0D-B647-C02E9460B7E6Q35925864-AC6FAF21-7C29-4E16-8F2A-887C6FA922B6Q36050013-100B3503-5E39-4A42-B4C8-AD6B7FBD403BQ36342001-3895A8E7-5B88-4905-967E-0CD92444FF00Q36698793-3C876289-F1E5-4F45-A2F3-DC99B77D71B5Q36933992-C98A5153-2B44-441F-9852-F4D68401302EQ37379671-389B5542-A346-4B1B-B8E6-9CF30A17B02FQ37431436-285D56D9-DE3F-4B50-823A-E9191F306E36Q37621873-B4A59A18-39CD-49AD-8F8E-9187FBDB7ED7Q37660670-38EB741F-A567-4BD9-A92E-7EF81877778BQ37695679-3FCF83F1-5C47-4CFA-8889-98837BEB4A9BQ37816649-4D7EBCE9-3BC4-49C5-82CD-7782D1572998Q38009792-4B9C9A05-7DB1-4A96-AC21-5D1A9A5BBE75Q38050479-761191DE-7AF2-4971-80B6-A0951467A1B6Q38050481-B1227DD7-B770-485B-BAF5-9197122A5FD9Q38603686-E02D373A-BA3C-47B8-8CF1-7B1BE87FBE6FQ39887068-C695273E-A081-4E40-8817-7B34C242B126Q39917871-CAAF98EC-7991-4B96-B459-907A796E5CA4Q40106402-B4FB5706-66B0-497A-B624-B6EC088E1EB9Q40121326-C95BD9CF-EDF3-43DE-9A2A-A77BA139D64DQ40165980-25619CCD-99B9-4ECC-A838-7108316A802AQ40242085-24916778-14B1-4055-976A-39AFCB5E1352Q40964647-FE6E5E7C-A1F0-4EEF-86BF-1FA1C0211BE3Q41019576-5B2C33BF-EF61-4D74-B866-71B92FEA9C64Q41910808-6170C71D-A012-4D2E-BE60-1BBA52E258E3Q41980961-427C8E0C-FF28-443F-BC51-C584499D6616
P2860
Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.
description
2004 nî lūn-bûn
@nan
2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@ast
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@en
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@nl
type
label
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@ast
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@en
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@nl
prefLabel
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@ast
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@en
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@nl
P2860
P50
P356
P1476
Crystal structure of the human ...... d to the therapeutic mAb OKT3.
@en
P2093
Lars Kjer-Nielsen
Lauren K Ely
P2860
P304
P356
10.1073/PNAS.0402295101
P407
P50
P577
2004-05-10T00:00:00Z