Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking.
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Glutamatergic substrates of drug addiction and alcoholismmGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in ratsNegative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic WindowGlutamatergic transmission in drug reward: implications for drug addictionThe metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in miceSubstituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.(3-Cyano-5-fluorophenyl)biaryl negative allosteric modulators of mGlu(5): Discovery of a new tool compound with activity in the OSS mouse model of addictionHomers regulate drug-induced neuroplasticity: implications for addictionInvolvement of metabotropic glutamate receptor 5 in brain reward deficits associated with cocaine and nicotine withdrawal and somatic signs of nicotine withdrawal.Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addictionCue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seekingInteroceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbensMetabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intakeEffects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependenceThe mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.Imaging glutamate homeostasis in cocaine addiction with the metabotropic glutamate receptor 5 positron emission tomography radiotracer [(11)C]ABP688 and magnetic resonance spectroscopyCognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.3-Cyano-5-fluoro-N-arylbenzamides as negative allosteric modulators of mGlu(5): Identification of easily prepared tool compounds with CNS exposure in rats.Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependenceAcute effects of nicotine amplify accumbal neural responses during nicotine-taking behavior and nicotine-paired environmental cues.Anxiolytic effects of nicotine in a rodent test of approach-avoidance conflict.Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in ratsFenobam sulfate inhibits cocaine-taking and cocaine-seeking behavior in rats: implications for addiction treatment in humans.Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models.Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking.Targeting glutamate homeostasis for potential treatment of nicotine dependence.Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.mGluR5 stimulates gliotransmission in the nucleus accumbens.D-cycloserine selectively decreases nicotine self-administration in rats with low baseline levels of response.Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine.Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEPSyntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.Recent advances in the design and development of novel negative allosteric modulators of mGlu(5)Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in ratsInteractive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in ratsThe effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task.Therapeutic potential of metabotropic glutamate receptor modulators.mGlu receptors and drug addiction.The "ups and downs" of signaling cascades in addiction.
P2860
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P2860
Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking.
description
2004 nî lūn-bûn
@nan
2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@ast
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@en
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@nl
type
label
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@ast
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@en
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@nl
prefLabel
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@ast
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@en
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@nl
P2093
P1476
Antagonism at metabotropic glu ...... d relapse to nicotine-seeking.
@en
P2093
Christian A Heidbreder
Daniel M Hutcheson
Maria Pilla
Michela Andreoli
Michela Tessari
P304
P356
10.1016/J.EJPHAR.2004.07.056
P407
P577
2004-09-01T00:00:00Z