Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A - sprookjes - yvandenbroek - TriplyDB

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

http://www.wikidata.org/entity/Q34520772

about

Targeting translation initiation in breast cancer Influenza a virus host shutoff disables antiviral stress-induced translation arrest Natural products as chemical probes Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer Eukaryotic initiation factor 4F: a vulnerability of tumor cells.RNA helicases in infection and disease.Targeting the eIF4F translation initiation complex: a critical nexus for cancer development A phase I dose-escalation study of eribulin and S-1 for metastatic breast cancer.Stress granules, P-bodies and cancer.Emerging therapeutics targeting mRNA translation Pateamine A-sensitive ribosome profiling reveals the scope of translation in mouse embryonic stem cells Inhibition of Eukaryotic Translation by the Antitumor Natural Product Agelastatin A.A phase I combination dose-escalation study of eribulin mesylate and gemcitabine in patients with advanced solid tumours: a study of the Princess Margaret Consortium.Therapeutic interventions to disrupt the protein synthetic machinery in melanoma The eIF4AIII RNA helicase is a critical determinant of human cytomegalovirus replication.Structures and cytotoxic evaluation of new and known acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge.TGF-beta-dependent and -independent roles of STRAP in cancer.The biological and therapeutic relevance of mRNA translation in cancer.Second-generation derivatives of the eukaryotic translation initiation inhibitor pateamine A targeting eIF4A as potential anticancer agents.Synthesis of a simplified triazole analogue of pateamine A.The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice.Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm.SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses.Stress Granule-Inducing Eukaryotic Translation Initiation Factor 4A Inhibitors Block Influenza A Virus Replication.Targeting RNA helicases in cancer: The translation trap.Gold Catalysis for Heterocyclic Chemistry: A Representative Case Study on Pyrone Natural Products.Beyond molecular tumor heterogeneity: protein synthesis takes control.Concise Synthesis of a Pateamine A Analogue with In Vivo Anticancer Activity Based on an Iron-Catalyzed Pyrone Ring Opening/Cross-Coupling.Myc, Oncogenic Protein Translation, and the Role of Polyamines.

P2860

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P2860

Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A

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2009 nî lūn-bûn

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Molecular Cancer Therapeutics

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P2093

Bruce A Littlefield

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Daniel Romo

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Galina Kuznetsov

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Hong Du

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Huiming Zhang

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Joanne Marsh

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Jue-Lon Shie

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Junke Liu

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Karen Tendyke

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Lana Parent

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P2860

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation.

Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B

Marine natural products and related compounds in clinical and advanced preclinical trials

Marine natural products as anticancer drugs.

Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product Pateamine A.

Substrate-dependent targeting of eukaryotic translation initiation factor 4A by pateamine A: negation of domain-linker regulation of activity.

Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A.

Inhibition of eukaryotic translation initiation by the marine natural product pateamine A.

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1250-1260

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10.1158/1535-7163.MCT-08-1026

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5

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19417157

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3026899

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