Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET - sprookjes - yvandenbroek - TriplyDB

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

http://www.wikidata.org/entity/Q34572780

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P-glycoprotein-dependent trafficking of nanoparticle-drug conjugates Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity Molecular Imaging of Membrane Transporters' Activity in Cancer: a Picture is Worth a Thousand Tubes.Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.[¹¹C]Rhodamine-123: synthesis and biodistribution in rodents.A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier.Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells).Factors that limit positron emission tomography imaging of p-glycoprotein density at the blood-brain barrier.A comparative small-animal PET evaluation of [11C]tariquidar, [11C]elacridar and (R)-[11C]verapamil for detection of P-glycoprotein-expressing murine breast cancer.PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration.Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2 Does transbilayer diffusion have a role in membrane transport of drugs?Radioligands targeting P-glycoprotein and other drug efflux proteins at the blood-brain barrier.Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.Synthesis and Evaluation of New Fluorine-18 Labeled Verapamil Analogs To Investigate the Function of P-Glycoprotein in the Blood-Brain Barrier.Interaction of 11C-tariquidar and 11C-elacridar with P-glycoprotein and breast cancer resistance protein at the human blood-brain barrier.

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P2860

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

http://www.wikidata.org/entity/Q34572780

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2011年の論文

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2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Lysosomal trapping of a radiol ...... or signal amplification in PET

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Lysosomal trapping of a radiol ...... or signal amplification in PET

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Lysosomal trapping of a radiol ...... or signal amplification in PET

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type

label

Lysosomal trapping of a radiol ...... or signal amplification in PET

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Lysosomal trapping of a radiol ...... or signal amplification in PET

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Lysosomal trapping of a radiol ...... or signal amplification in PET

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prefLabel

Lysosomal trapping of a radiol ...... or signal amplification in PET

@ast

Lysosomal trapping of a radiol ...... or signal amplification in PET

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Lysosomal trapping of a radiol ...... or signal amplification in PET

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PNAS.1014641108

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Lysosomal trapping of a radiol ...... or signal amplification in PET

@en

P2093

Jeih-San Liow

http://www.w3.org/2001/XMLSchema#string

Kyle R Brimacombe

http://www.w3.org/2001/XMLSchema#string

Matthew D Hall

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Michael M Gottesman

http://www.w3.org/2001/XMLSchema#string

Pavitra Kannan

http://www.w3.org/2001/XMLSchema#string

Robert B Innis

http://www.w3.org/2001/XMLSchema#string

Sami S Zoghbi

http://www.w3.org/2001/XMLSchema#string

Sanjay Telu

http://www.w3.org/2001/XMLSchema#string

Victor W Pike

http://www.w3.org/2001/XMLSchema#string

William C Kreisl

http://www.w3.org/2001/XMLSchema#string

P2860

Multidrug resistance in cancer: role of ATP-dependent transporters

The role of lysosomes in limiting drug toxicity in mice.

P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.

N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier

11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.

Commentary. Lysosomotropic agents.

Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications.

Tamoxifen inhibits acidification in cells independent of the estrogen receptor

Cellular changes in boric acid-treated DU-145 prostate cancer cells.

The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).

P304

2593-2598

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scholarly article

P356

10.1073/PNAS.1014641108

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P407

P433

6

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P478

108

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P50

Christer Halldin

P577

2011-01-24T00:00:00Z

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49781561

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P698

21262843

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P921

desmethyl loperamide

P932

3038699

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