N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier
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Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable EpilepsyScreening compounds with a novel high-throughput ABCB1-mediated efflux assay identifies drugs with known therapeutic targets at risk for multidrug resistance interferenceLysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PETReduced accumulation of platinum drugs is not observed in drug-resistant ovarian cancer cell lines derived from cisplatin-treated patientsThe Inhibitor Ko143 Is Not Specific for ABCG2The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2).Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo(R)-[(11)C]verapamil is selectively transported by murine and human P-glycoprotein at the blood-brain barrier, and not by MRP1 and BCRP.Overlapping substrate and inhibitor specificity of human and murine ABCG2.Bioluminescent imaging of drug efflux at the blood-brain barrier mediated by the transporter ABCG2Use of PET Imaging to Evaluate Transporter-Mediated Drug-Drug Interactions.Imaging transporters: Transforming diagnostic and therapeutic development.Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.Imaging P-glycoprotein function in rats using [(11)C]-N-desmethyl-loperamide.(18)F-FCWAY, a serotonin 1A receptor radioligand, is a substrate for efflux transport at the human blood-brain barrierSustained Increase in the Oral Bioavailability of Loperamide after a Single Oral Dose of HM30181, a P-glycoprotein Inhibitor, in Healthy Male Participants.
P2860
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P2860
N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier
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2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
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2010年の論文
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2010年論文
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2010年論文
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name
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@ast
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@en
type
label
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@ast
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@en
prefLabel
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@ast
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@en
P2093
P2860
P356
P1476
N-desmethyl-loperamide is sele ...... ers at the blood-brain barrier
@en
P2093
Andrew K Taku
Cheryl Morse
Jeih-San Liow
Kyle R Brimacombe
Matthew D Hall
Michael M Gottesman
Pavitra Kannan
Robert B Innis
Sami S Zoghbi
Victor W Pike
P2860
P304
P356
10.1124/DMD.109.031161
P577
2010-03-08T00:00:00Z