Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.
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Mapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cellsDiscovery of Compound A--a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activityDevelopment of macromolecular prodrug for rheumatoid arthritisSelective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitroThe calcitonin and glucocorticoids combination: mechanistic insights into their class-effect synergy in experimental arthritisGlucose kinetics in the collagen-induced arthritis model: an all-in-one model to assess both efficacy and metabolic side effects of glucocorticoidsHow the venom from the ectoparasitoid Wasp nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines.Bronchial epithelial cells are rendered insensitive to glucocorticoid transactivation by transforming growth factor-β1.Compound A Inhibits Bladder Cancer Growth Predominantly via Glucocorticoid Receptor TransrepressionCrosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatasesMinireview: latest perspectives on antiinflammatory actions of glucocorticoids.Class I lysine deacetylases promote glucocorticoid-induced transcriptional repression through functional interaction with LSD1.Ginsenoside Rh1 potentiates dexamethasone's anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance.Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.Corticosteroids and muscle wasting: role of transcription factors, nuclear cofactors, and hyperacetylationSerum cholesterol selectively regulates glucocorticoid sensitivity through activation of JNKNoncanonical mechanisms to regulate nuclear receptor signaling.LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.The stress of starvation: glucocorticoid restraint of beta cell development.The positive correlations of apolipoprotein E with disease activity and related cytokines in systemic lupus erythematosusGlucocorticoid-targeted therapies for the treatment of rheumatoid arthritis.The value of glucocorticoid co-therapy in different rheumatic diseases--positive and adverse effectsDynamic access of the glucocorticoid receptor to response elements in chromatin.Glucocorticosteroids: current and future directions.Biochemical basis of asthma therapy.Differential targeting of androgen and glucocorticoid receptors induces ER stress and apoptosis in prostate cancer cells: a novel therapeutic modality.Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.Dexamethasone-mediated changes in adipose triacylglycerol metabolism are exaggerated, not diminished, in the absence of a functional GR dimerization domain.Expression level of the growth factor progranulin is related with development of systemic lupus erythematosus.Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory EffectsAlternate glucocorticoid receptor ligand binding structures influence outcomes in an in vivo tissue regeneration modelModulation of transcription parameters in glucocorticoid receptor-mediated repression.Role of dual specificity phosphatases in biological responses to glucocorticoids.Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblastsMinireview: live and let die: molecular effects of glucocorticoids on bone cells.Revisiting steroid treatment for septic shock: molecular actions and clinical effects--a review.The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.NF-kappaB signaling: multiple angles to target OA.IL-1β induction of MUC5AC gene expression is mediated by CREB and NF-κB and repressed by dexamethasone.The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.
P2860
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P2860
Selective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.
description
2007 nî lūn-bûn
@nan
2007 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Selective glucocorticoid recep ...... an improved therapeutic index.
@ast
Selective glucocorticoid recep ...... an improved therapeutic index.
@en
Selective glucocorticoid receptor agonists
@nl
type
label
Selective glucocorticoid recep ...... an improved therapeutic index.
@ast
Selective glucocorticoid recep ...... an improved therapeutic index.
@en
Selective glucocorticoid receptor agonists
@nl
prefLabel
Selective glucocorticoid recep ...... an improved therapeutic index.
@ast
Selective glucocorticoid recep ...... an improved therapeutic index.
@en
Selective glucocorticoid receptor agonists
@nl
P2093
P1476
Selective glucocorticoid recep ...... an improved therapeutic index
@en
P2093
Hartmut Rehwinkel
Heike Schäcke
Khusru Asadullah
P304
P356
10.1016/J.MCE.2007.05.014
P577
2007-05-31T00:00:00Z