about
The plant-derived glucocorticoid receptor agonist Endiandrin A acts as co-stimulator of colonic epithelial sodium channels (ENaC) via SGK-1 and MAPKsMapracorat, a novel selective glucocorticoid receptor agonist, inhibits hyperosmolar-induced cytokine release and MAPK pathways in human corneal epithelial cellsDissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effectsBOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cellsSelective non-steroidal glucocorticoid receptor agonists attenuate inflammation but do not impair intestinal epithelial cell restitution in vitroEvaluation of the selective glucocorticoid receptor agonist compound A for ototoxic effectsA combination of ultrahigh throughput PathHunter and cytokine secretion assays to identify glucocorticoid receptor agonists.Correlation of skin blanching and percutaneous absorption for glucocorticoid receptor agonists by matrix-assisted laser desorption ionization mass spectrometry imaging and liquid extraction surface analysis with nanoelectrospray ionization mass specSelective glucocorticoid receptor agonists (SEGRAs): novel ligands with an improved therapeutic index.Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin LymphomasOctahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists.Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis.Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases.Mapracorat, a novel non-steroidal selective glucocorticoid receptor agonist for the treatment of allergic conjunctivitis.Novel glucocorticoid receptor agonists in the treatment of asthma.Sutherlandia frutescens modulates adrenal hormone biosynthesis, acts as a selective glucocorticoid receptor agonist (SEGRA) and displays anti-mineralocorticoid properties.2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists.Identification of highly efficacious glucocorticoid receptor agonists with a potential for reduced clinical bone side effects.Exploring Glucocorticoid Receptor Agonists Mechanism of Action Through Mass Cytometry and Radial Visualizations.Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).Eosinophil as a cellular target of the ocular anti-allergic action of mapracorat, a novel selective glucocorticoid receptor agonist.Ginsenoside Rg1, a novel glucocorticoid receptor agonist of plant origin, maintains glucocorticoid efficacy with reduced side effects.Beneficial pharmacological effects of selective glucocorticoid receptor agonist in external eye diseases.Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity.Interplay of the inflammatory and stress systems in a hepatic cell line: interactions between glucocorticoid receptor agonists and interleukin-6.Discovery of quinolines as selective glucocorticoid receptor agonists.Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis.Glucocorticoid receptor agonist compound K regulates Dectin-1-dependent inflammatory signaling through inhibition of reactive oxygen species.Highly tractable, sub-nanomolar non-steroidal glucocorticoid receptor agonists.Comparison of two structurally diverse glucocorticoid receptor agonists: cortivazol selectively regulates a distinct set of genes separate from dexamethasone in CEM cells.Identification of the pregnancy hormone relaxin as glucocorticoid receptor agonist.The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist.Mapracorat, a selective glucocorticoid receptor agonist, causes apoptosis of eosinophils infiltrating the conjunctiva in late-phase experimental ocular allergy.Compound A, a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice.Anti-allergic effects of mapracorat, a novel selective glucocorticoid receptor agonist, in human conjunctival fibroblasts and epithelial cellsStructure guided design of 5-arylindazole glucocorticoid receptor agonists and antagonists.5-Functionalized indazoles as glucocorticoid receptor agonists.Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X.Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids.
P921
Q21133896-BD2437FA-6B6E-4988-94A2-23296D38BEA8Q24619895-81C9B358-B1ED-4BFC-80E1-361CFC32703DQ24630458-0FD180C7-9565-452B-836E-40159D0D912FQ24644700-6E7BFAAE-6F89-47AB-9B52-5CCE89E8EB3FQ28479065-6F6D8B5D-E793-48B8-8DE7-560BB2ECF08FQ30382813-6D19E073-3B93-4528-AE4D-1AA78A76A030Q33387093-866D7A10-86E9-4BD2-AB16-2B36AEB09AB9Q33447556-07784C10-0996-49F8-B586-4F326F92DFA4Q34650477-0C214B44-7F36-45DA-AA52-B1DCFB0B7EAEQ34670913-0EC9EADC-49BE-4E64-A503-81762FDE01DCQ34950995-EE6DFC5C-591F-4081-8FB4-DA2AFCF124A4Q36881025-78BC4D80-7EE1-4F5B-B8B8-B2BCF88EAA06Q37374607-0D3E9686-0667-4C6C-907B-117A0111CC7AQ37447509-260BF8F1-FB3B-4FAC-93B3-3741F7B1071AQ38265391-355D0BB7-271E-43A7-86A3-8F18321B65DDQ38570469-2BA00137-30DD-44C9-AD17-54E98D97E70DQ38711299-B1DE66FF-6ED2-4595-9013-BCB356F31571Q38906978-0C90AFDE-B290-492F-9D5B-C77CF573FA97Q39026110-95774A78-EEB0-4D67-AD0E-1EAF4CCF16AFQ39116801-7567FC5D-4506-4EB4-A652-18ECEBA01F9DQ39296353-784781D0-EE0C-42C0-849E-75E34AE59F75Q39423430-F030BECE-D44B-4435-BE9E-E3C14F00793EQ39526087-DF855449-9397-4814-81A4-CE01E55A48C1Q39541907-9708E421-9B75-425B-BE11-83B7B0B6D965Q39604255-50A136D9-0F97-40A0-B36B-6190E2E03FE8Q39649851-F8EB2902-B0B5-4195-88E3-E8CD7A8E6E92Q39665075-39C04D31-7BB6-4719-889D-AAEF5BC6F75CQ39665721-B12F5B4C-60A5-40A7-8D49-7C7E7C033C60Q39803155-297685CD-0582-4407-9522-D404D63F79E2Q39826553-9711622D-9900-4767-95BA-85339E07DEE6Q40112711-7C242FDF-716F-4253-9322-D71F8E4052EAQ40529442-43E5B109-A7F0-449B-BC9C-434CEDF2ADD8Q40570548-40BDFEF9-FEC9-4232-8F93-CD54F25434C4Q40816092-9801B8C0-3461-4AF4-BEE4-61A666FFAA3BQ42030632-D1A91AB3-12D1-4E25-9B8F-76F38F8C2AF6Q42743183-E8924AD4-7DEF-4A80-BFFE-685255DCFD54Q43063385-C2D1E4DC-F72B-4FCA-AC3D-935A8B640D11Q43081875-48C4EB86-ED80-4CE9-888D-C7A71BB40771Q43225993-CFBE7828-BEB8-4071-994C-43D65B4F9AA1Q43288611-6E23FBE8-1A4E-4693-99FA-FD0104AC176C
P921
description
class of chemical compounds
@en
name
glucocorticoid receptor agonist
@en
type
label
glucocorticoid receptor agonist
@en
prefLabel
glucocorticoid receptor agonist
@en