Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression
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Middle East respiratory syndrome coronavirus: transmission, virology and therapeutic targeting to aid in outbreak controlStructural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitinPotent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.Structural view and substrate specificity of papain-like protease from avian infectious bronchitis virus.Murine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like diseaseSARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzymeMiddle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress ResponsesX-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets.Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoVRecognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease.p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1X-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.Host Factors in Coronavirus Replication.Viral deubiquitinases: role in evasion of anti-viral innate immunity.SARS-unique fold in the Rousettus bat coronavirus HKU9.A Naturally Occurring Recombinant Enterovirus Expresses a Torovirus Deubiquitinase.Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species.Biochemical Characterization of Middle East Respiratory Syndrome Coronavirus Helicase.Structurally guided removal of deISGylase biochemical activity from papain-Like protease originating from the Middle East Respiratory Syndrome Virus.Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances.A mobile loop near the active site acts as a switch between the dual activities of a viral protease/deubiquitinase.Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication.Deubiquitylating enzymes and drug discovery: emerging opportunities.MERS-CoV: Understanding the Latest Human Coronavirus Threat.The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
P2860
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P2860
Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppression
description
2014 nî lūn-bûn
@nan
2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Crystal structure of the Middl ...... e in innate immune suppression
@ast
Crystal structure of the Middl ...... e in innate immune suppression
@en
Crystal structure of the Middle East respiratory syndrome coronavirus
@nl
type
label
Crystal structure of the Middl ...... e in innate immune suppression
@ast
Crystal structure of the Middl ...... e in innate immune suppression
@en
Crystal structure of the Middle East respiratory syndrome coronavirus
@nl
prefLabel
Crystal structure of the Middl ...... e in innate immune suppression
@ast
Crystal structure of the Middl ...... e in innate immune suppression
@en
Crystal structure of the Middle East respiratory syndrome coronavirus
@nl
P2093
P2860
P50
P921
P356
P1476
Crystal structure of the Middl ...... e in innate immune suppression
@en
P2093
Ben A Bailey-Elkin
Dennis K Ninaber
Garrett G Johnson
Peter J Bredenbeek
Robert C M Knaap
Tim J Dalebout
P2860
P304
34667-34682
P356
10.1074/JBC.M114.609644
P407
P577
2014-10-15T00:00:00Z