about
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TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulumHuman HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulumRecruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membraneViral OTU deubiquitinases: a structural and functional comparisonSARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulumIntegrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus-induced remodeling of endoplasmic reticulum membranes.Papain-Like Protease 1 from Transmissible Gastroenteritis Virus: Crystal Structure and Enzymatic Activity toward Viral and Cellular SubstratesDeubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cellsThe ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathwayThe E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation.Crystal structure of the Middle East respiratory syndrome coronavirus (MERS-CoV) papain-like protease bound to ubiquitin facilitates targeted disruption of deubiquitinating activity to demonstrate its role in innate immune suppressionOvarian tumor domain-containing viral proteases evade ubiquitin- and ISG15-dependent innate immune responses.A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.Arterivirus and nairovirus ovarian tumor domain-containing Deubiquitinases target activated RIG-I to control innate immune signaling.Middle East Respiratory Coronavirus Accessory Protein 4a Inhibits PKR-Mediated Antiviral Stress ResponsesRegulation of the innate immune system by ubiquitin and ubiquitin-like modifiers.Arterivirus molecular biology and pathogenesis.Host Factors in Coronavirus Replication.Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex.Structure and Function of Viral Deubiquitinating Enzymes.Interaction of the innate immune system with positive-strand RNA virus replication organelles.The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.Antiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus.Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication.193CS17-5. Arteri- and nairovirus OTU domain-containing proteases target ubiquitin-regulated factors in the RLR-mediated innate immune signaling pathwayViral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus InfectionsThe deubiquitinating activity of Middle East respiratory syndrome coronavirus papain-like protease delays the innate immune response and enhances virulence in a mouse model
P50
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P50
description
moleculair viroloog, verbonden aan het LUMC
@nl
researcher
@en
name
Marjolein Kikkert
@de
Marjolein Kikkert
@en
Marjolein Kikkert
@fr
Marjolein Kikkert
@nl
type
label
Marjolein Kikkert
@de
Marjolein Kikkert
@en
Marjolein Kikkert
@fr
Marjolein Kikkert
@nl
prefLabel
Marjolein Kikkert
@de
Marjolein Kikkert
@en
Marjolein Kikkert
@fr
Marjolein Kikkert
@nl
P106
P31
P496
0000-0002-5779-7386