Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes.
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Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected ErythrocytesSurface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSAVar2CSA minimal CSA binding region is located within the N-terminal regionTargeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacityAntigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malariaStructural insight into epitopes in the pregnancy-associated malaria protein VAR2CSAA method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in Plasmodium falciparum infected erythrocytes.Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies.Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolatesEvaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs.Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.Advances and challenges in malaria vaccine development.Dual stage synthesis and crucial role of cytoadherence-linked asexual gene 9 in the surface expression of malaria parasite var proteinsHigh avidity antibodies to full-length VAR2CSA correlate with absence of placental malaria.Insect cells are superior to Escherichia coli in producing malaria proteins inducing IgG targeting PfEMP1 on infected erythrocytesInduction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins.Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites.Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment FcμStructure of the DBL3X-DBL4ε region of the VAR2CSA placental malaria vaccine candidate: insight into DBL domain interactionsPlasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressedEvidence for globally shared, cross-reacting polymorphic epitopes in the pregnancy-associated malaria vaccine candidate VAR2CSA.Multilaboratory approach to preclinical evaluation of vaccine immunogens for placental malaria.Overproduction, purification and crystallization of a chondroitin sulfate A-binding DBL domain from a Plasmodium falciparum var2csa-encoded PfEMP1 proteinPregnancy malaria: cryptic disease, apparent solution.Antibodies to Escherichia coli-expressed C-terminal domains of Plasmodium falciparum variant surface antigen 2-chondroitin sulfate A (VAR2CSA) inhibit binding of CSA-adherent parasites to placental tissue.Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites.Adhesion of Plasmodium falciparum infected erythrocytes in ex vivo perfused placental tissue: a novel model of placental malaria.An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype.Induction of adhesion-inhibitory antibodies against placental Plasmodium falciparum parasites by using single domains of VAR2CSA.Optimizing expression of the pregnancy malaria vaccine candidate, VAR2CSA in Pichia pastoris.Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes.Human pregnancy-associated malaria-specific B cells target polymorphic, conformational epitopes in VAR2CSA.Structural basis for the adherence of Plasmodium falciparum-infected erythrocytes to chondroitin 4-sulfate and design of novel photoactivable reagents for the identification of parasite adhesive proteins.VAR2CSA domains expressed in Escherichia coli induce cross-reactive antibodies to native protein.
P2860
Q27301377-D582DB2D-3EDA-4E3C-B074-269AB08CED8EQ27313623-B3A3218C-3B14-4FBF-9C4F-6002B7F34595Q27349502-943C33B8-14F6-4130-A44D-1AE3AE4769CEQ28744428-6C672DE4-835E-44FD-8A45-888959A85A9EQ30042328-30193C0A-DBB1-41A1-BB36-6D4A395988D9Q30603697-64B7EC5A-4E93-4B65-9906-8E7CDF9F5BFBQ33320197-64D109F7-BFC2-4CA9-8502-99620C678215Q33340826-8A1846DB-4B06-4404-8321-A2C14FBC5467Q33634689-02747D7A-8A2D-445C-AF07-D909A2F4B2D0Q33815803-45D92B3B-0718-4937-B5E6-8ABB560C4532Q33822296-1EF69907-9FA9-4467-8395-D03C321E9027Q33826049-AC8265F7-317E-4925-8B4C-1EEBC38DC563Q33826076-748EF5E5-62E4-452B-A413-04CEE38FCF62Q33846617-4C14541E-E4EC-491D-84A8-7B78FF9E5CEBQ34095324-67913712-4B4E-4A97-AB4E-9998A0E85811Q34145333-9D63FB92-2678-4B42-8775-BFB773898AABQ34151684-847C7104-1B5C-4608-9600-5842DE668E40Q34326742-9B883DAF-2237-4176-81D6-5D63A3334457Q34367020-179D9771-6073-41E8-B17C-ED842F2A8618Q34660001-78EF598B-F132-403B-9474-BEF654FC101EQ34853037-669D37F6-82B6-45D3-AB43-C8B89217E6C7Q34988334-B58B88A5-3E7F-464A-A52D-9266F42F6250Q35738477-416F9478-688B-4C7B-AFC3-C6361B1A4293Q36053493-C8C5F13E-A74C-41DB-9A1D-F998C58A9C53Q36139430-20F6359E-DC10-401D-BC8A-ED4EC149FAE0Q36177571-6ADD1CA2-C45E-4A1F-99DB-759401F4DBF3Q36539548-04C5917F-FD5E-41CF-B81C-7357FF5C961EQ36558721-C05F0312-9D11-470D-9D7A-AE3C7CE6C04CQ36640619-D3575584-F6E0-4055-AF97-38443AD4B79BQ36677527-37D1F54E-3055-4627-B3D4-AD31788E7B95Q36804761-C59924D6-1B85-4518-8B26-31CCF31E631DQ36891434-14D4E4A4-E63B-4B04-84A5-F6848376CDAEQ36938125-2E244F27-9B7E-40D1-80F8-4A61D60543BDQ36974515-C4FCF1E5-263B-4ED3-B073-7A159AD44469Q37204480-1C5F9F9A-93FF-409C-AA44-FF3F84E17A10Q37271796-D9D21352-5D3A-48F9-917C-3251A673C714Q37408633-0A8B28E1-C487-4DC0-8CD3-9DEA4CBF2EB3Q37426131-4D1D4782-6EB3-4E5B-94BD-A27EC2ECB00CQ38307897-07695971-C854-47FE-84B0-F46BA7036ED9Q46608178-FD9C8C6C-1A8C-4097-8435-6DC47BC2FCFA
P2860
Baculovirus-expressed constructs induce immunoglobulin G that recognizes VAR2CSA on Plasmodium falciparum-infected erythrocytes.
description
2006 nî lūn-bûn
@nan
2006 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@ast
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@en
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@nl
type
label
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@ast
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@en
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@nl
prefLabel
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@ast
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@en
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@nl
P2860
P50
P356
P1476
Baculovirus-expressed construc ...... ciparum-infected erythrocytes.
@en
P2093
Anja T R Jensen
Madeleine Dahlbäck
P2860
P304
P356
10.1128/IAI.01617-05
P407
P577
2006-07-01T00:00:00Z