MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src - sprookjes - yvandenbroek - TriplyDB

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

http://www.wikidata.org/entity/Q34783859

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Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7 Erk5 controls Slug expression and keratinocyte activation during wound healing CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response Mip1, an MEKK2-interacting protein, controls MEKK2 dimerization and activation.Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation Applying ligands profiling using multiple extended electron distribution based field templates and feature trees similarity searching in the discovery of new generation of urea-based antineoplastic kinase inhibitors Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways.Essential role of the T cell-specific adapter protein in the activation of LCK in peripheral T cells.MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.Calcium regulation of EGF-induced ERK5 activation: role of Lad1-MEKK2 interaction.G alpha(q) acts as an adaptor protein in protein kinase C zeta (PKCzeta)-mediated ERK5 activation by G protein-coupled receptors (GPCR).MicroRNA-520b inhibits growth of hepatoma cells by targeting MEKK2 and cyclin D1.SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression The role of specific mitogen-activated protein kinase signaling cascades in the regulation of steroidogenesis Regulation of gap junctions by tyrosine protein kinases.MEKK2 mediates an alternative β-catenin pathway that promotes bone formation Regulation of MAPKs by growth factors and receptor tyrosine kinases Role of mitogen-activated protein kinase kinase kinases in signal integration.Overexpression of MEKK2 is associated with colorectal carcinogenesis.ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells.Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2.The kinase ALK stimulates the kinase ERK5 to promote the expression of the oncogene MYCN in neuroblastoma.Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis.MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.Modulation of Lck function through multisite docking to T cell-specific adapter protein.Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses.The carboxyl-terminal segment of the adaptor protein ALX directs its nuclear export during T cell activation.Dimerization through the catalytic domain is essential for MEKK2 activation.The ALX Src homology 2 domain is both necessary and sufficient to inhibit T cell receptor/CD28-mediated up-regulation of RE/AP.Extracellular signal-regulated kinase 5 promotes acute cellular and systemic inflammation.Targeting the BMK1 MAP kinase pathway in cancer therapy.Cancer biology: Enzyme meets a surprise target.MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.ERK5 regulation in naïve T-cell activation and survival.Characterization of the MEK5-ERK5 module in human neutrophils and its relationship to ERK1/ERK2 in the chemotactic response.Homogeneous time-resolved fluorescence resonance energy transfer assay for measurement of Phox/Bem1p (PB1) domain heterodimerization.Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.MAPK and PI3K Signaling: at the Crossroads of Neural Crest Development.

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P2860

MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src

http://www.wikidata.org/entity/Q34783859

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2003 nî lūn-bûn

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2003 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2003 թվականի ապրիլին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

@zh-tw

2003年论文

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name

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@ast

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@en

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@nl

type

label

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@ast

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@en

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@nl

prefLabel

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@ast

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@en

MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

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MCB.23.7.2298-2308.2003

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Molecular and Cellular Biology

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MEK kinase 2 and the adaptor p ...... pidermal growth factor via Src

@en

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Gary L Johnson

http://www.w3.org/2001/XMLSchema#string

Junjie Mei

http://www.w3.org/2001/XMLSchema#string

Kamala Kesavan

http://www.w3.org/2001/XMLSchema#string

Ruihua Fan

http://www.w3.org/2001/XMLSchema#string

Steven M Anderson

http://www.w3.org/2001/XMLSchema#string

Timothy P Garrington

http://www.w3.org/2001/XMLSchema#string

Weiyong Sun

http://www.w3.org/2001/XMLSchema#string

Xudong Wei

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of the MEF2 family of transcription factors by p38

Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors

Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation

Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites

Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation

Components of a new human protein kinase signal transduction pathway

SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

Extracellular signal regulated kinase 5 (ERK5) is required for the differentiation of muscle cells

P304

2298-2308

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scholarly article

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10.1128/MCB.23.7.2298-2308.2003

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7

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23

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Erwin W. Gelfand

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2003-04-01T00:00:00Z

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10853691

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12640115

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150715

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