Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles
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Neurobiological Insights from mGlu Receptor Allosteric Modulation.VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo EfficacyPartial mGlu₅ Negative Allosteric Modulators Attenuate Cocaine-Mediated Behaviors and Lack Psychotomimetic-Like Effects.Iodonium ylide-mediated radiofluorination of 18F-FPEB and validation for human useMetabotropic glutamate receptor 5 - a promising target in drug development and neuroimaging.Development of Novel, CNS Penetrant Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 1 (mGlu1), Based on an N-(3-Chloro-4-(1,3-dioxoisoindolin-2-yl)phenyl)-3-methylfuran-2-carboxamide Scaffold, That Potentiate Wild TypeIncreased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in MiceFunctional modulation of G-protein coupled receptors during Parkinson disease-like neurodegeneration.Synthesis of (18)F-Arenes from Spirocyclic Iodonium(III) Ylides via Continuous-Flow MicrofluidicsUtilizing GCaMP transgenic mice to monitor endogenous Gq/11-coupled receptors.Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation.Differential Pharmacology and Binding of mGlu2 Receptor Allosteric Modulators.
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P2860
Relationship between in vivo receptor occupancy and efficacy of metabotropic glutamate receptor subtype 5 allosteric modulators with different in vitro binding profiles
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2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
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type
label
Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
@en
Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
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Relationship between in vivo r ...... rent in vitro binding profiles
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Andrew S Felts
Carrie K Jones
J Scott Daniels
Jerri M Rook
Kyle A Emmitte
Mohammad S Ansari
Mohammed N Tantawy
Robert M Kessler
Shaun R Stauffer
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P356
10.1038/NPP.2014.245
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2014-09-22T00:00:00Z
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1009760216