Adaptors as central mediators of signal transduction in immune cells. - sprookjes - yvandenbroek - TriplyDB

Adaptors as central mediators of signal transduction in immune cells.

Adaptors as central mediators of signal transduction in immune cells.

http://www.wikidata.org/entity/Q35055629

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Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif Expression, refolding and crystallizations of the Grb2-like (GADS) C-terminal SH3 domain complexed with a SLP-76 motif peptide Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL Nore1B regulates TCR signaling via Ras and Carma1 Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling.An immunology primer for computational modelers TIM-3 Suppresses Anti-CD3/CD28-Induced TCR Activation and IL-2 Expression through the NFAT Signaling Pathway Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond Identification of a new transmembrane adaptor protein that constitutively binds Grb2 in B cells The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-kappaB, is dispensable for T cell development and/or T cell effector functions Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors Impaired immune responses and prolonged allograft survival in Sly1 mutant mice Competition between SLP76 and LAT for PLCγ1 binding in resting T cells.In vivo significance of ITK-SLP-76 interaction in cytokine production.Structural basis for recognition of the T cell adaptor protein SLP-76 by the SH3 domain of phospholipase Cgamma1 T cell receptor-induced activation of phospholipase C-gamma1 depends on a sequence-independent function of the P-I region of SLP-76.ShcA mediates the dominant pathway to extracellular signal-regulated kinase activation during early thymic development Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo.SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering.The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.Functional cooperation between the proteins Nck and ADAP is fundamental for actin reorganization.Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.Ablation of SLP-76 signaling after T cell priming generates memory CD4 T cells impaired in steady-state and cytokine-driven homeostasis.Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76-ADAP Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production The importance of LAT in the activation, homeostasis, and regulatory function of T cells T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells A new function for LAT and CD8 during CD8-mediated apoptosis that is independent of TCR signal transduction MyD88 and Src are differentially regulated in Kupffer cells of males and proestrus females following hypoxia.Evidence for the requirement of ITAM domains but not SLP-76/Gads interaction for integrin signaling in hematopoietic cells.Conditional deletion of SLP-76 in mature T cells abrogates peripheral immune responses.SH2 and PTB domains in tyrosine kinase signaling.Remembrance of antigens past: new insights into memory T cells.Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

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Adaptors as central mediators of signal transduction in immune cells.

http://www.wikidata.org/entity/Q35055629

description

2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Adaptors as central mediators of signal transduction in immune cells.

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Adaptors as central mediators of signal transduction in immune cells.

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Adaptors as central mediators of signal transduction in immune cells.

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Adaptors as central mediators of signal transduction in immune cells.

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Adaptors as central mediators of signal transduction in immune cells.

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Adaptors as central mediators of signal transduction in immune cells.

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Nature Immunology

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Adaptors as central mediators of signal transduction in immune cells.

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Andrew L Singer

http://www.w3.org/2001/XMLSchema#string

Gary A Koretzky

http://www.w3.org/2001/XMLSchema#string

Martha S Jordan

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P2860

The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM

Association of Nck with tyrosine-phosphorylated SLP-76 in activated T lymphocytes

SLP-76 and Vav function in separate, but overlapping pathways to augment interleukin-2 promoter activity

An essential role for BLNK in human B cell development

Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling

p56(dok-2) as a cytokine-inducible inhibitor of cell proliferation and signal transduction

Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling

Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

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110-116

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10.1038/NI0203-110

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12555096

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