Reductions in serum IGF-1 during aging impair health span. - sprookjes - yvandenbroek - TriplyDB

Reductions in serum IGF-1 during aging impair health span.

Reductions in serum IGF-1 during aging impair health span.

http://www.wikidata.org/entity/Q35080501

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Cellular senescence in aging and age-related disease: from mechanisms to therapy Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans The somatotropic axis and longevity in mice Opposing impacts on healthspan and longevity by limiting dietary selenium in telomere dysfunctional mice Biological ageing and frailty markers in breast cancer patients IGF-1 Receptor Insufficiency Leads to Age-Dependent Attenuation of Osteoblast Differentiation.Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human aging.Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition.IGF-1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging Identification of ageing-associated naturally occurring peptides in human urine The somatotropic axis and aging: Benefits of endocrine defects.Regulation of skeletal growth and mineral acquisition by the GH/IGF-1 axis: Lessons from mouse models.IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence.Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.The impact of adjuvant chemotherapy in older breast cancer patients on clinical and biological aging parameters.mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress.Circulating Concentrations of Growth Differentiation Factor 11 Are Heritable and Correlate With Life Span.The type I insulin-like growth factor regulates the liver stromal response to metastatic colon carcinoma cells.mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass.Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice.A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice.Porf-2 = Arhgap39 = Vilse: A Pivotal Role in Neurodevelopment, Learning and Memory

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P2860

Reductions in serum IGF-1 during aging impair health span.

http://www.wikidata.org/entity/Q35080501

description

2013 nî lūn-bûn

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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Reductions in serum IGF-1 during aging impair health span.

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Reductions in serum IGF-1 during aging impair health span.

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Reductions in serum IGF-1 during aging impair health span.

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Reductions in serum IGF-1 during aging impair health span.

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Reductions in serum IGF-1 during aging impair health span.

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Reductions in serum IGF-1 during aging impair health span

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Garry A Williams

http://www.w3.org/2001/XMLSchema#string

Gene B Hubbard

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Hui Sun

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Laura Klein

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Luis Cardoso

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Martin L Adamo

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Mitchell B Schaffler

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Radhika H Muzumdar

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Roger P Farrar

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Ronald W Matheny

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P2860

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

Caloric restriction delays disease onset and mortality in rhesus monkeys

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Liver-derived IGF-I regulates mean life span in mice

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Insulin-like growth factor-I regulates the liver microenvironment in obese mice and promotes liver metastasis.

Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo.

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408-418

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10.1111/ACEL.12188

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3

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13

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24341939

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