Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.
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Pancreatic β Cell Mass DeathRecent Advances in Disease Modeling and Drug Discovery for Diabetes Mellitus Using Induced Pluripotent Stem CellsNotch Signaling in Pancreatic DevelopmentDevelopmental Pathways Direct Pancreatic Cancer Initiation from Its Cellular OriginProgenitor Epithelium: Sorting Out Pancreatic LineagesTranscription factor-mediated reprogramming toward hematopoietic stem cellsTranscription factor regulation of pancreatic organogenesis, differentiation and maturationDirected pancreatic acinar differentiation of mouse embryonic stem cells via embryonic signalling molecules and exocrine transcription factorsPtf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanismThe nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesisMind bomb 1 is required for pancreatic β-cell formationRNA profiling and chromatin immunoprecipitation-sequencing reveal that PTF1a stabilizes pancreas progenitor identity via the control of MNX1/HLXB9 and a network of other transcription factorsParkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expressionHuman pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling.Transdifferentiation of pancreatic cells by loss of contact-mediated signalingNkx6.1 is essential for maintaining the functional state of pancreatic beta cells.Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning.Suppression of Ptf1a activity induces acinar-to-endocrine conversion.Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineageTranscriptional regulation of α-cell differentiation.Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor.The stress of starvation: glucocorticoid restraint of beta cell development.Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate.Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell developmentNkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity.Regulation of Neurod1 contributes to the lineage potential of Neurogenin3+ endocrine precursor cells in the pancreasSox9: a master regulator of the pancreatic program.Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3.Dominant and context-specific control of endodermal organ allocation by Ptf1a.Progenitor cell domains in the developing and adult pancreas.Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell linesCompetence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas developmentMolecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney DiseaseProgenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regenerationNotch-mediated patterning and cell fate allocation of pancreatic progenitor cells.Deconstructing pancreas developmental biology.A pancreatic exocrine-like cell regulatory circuit operating in the upper stomach of the sea urchin Strongylocentrotus purpuratus larva.The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal CellsA Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation
P2860
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P2860
Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Nkx6 transcription factors and ...... potent pancreatic progenitors.
@ast
Nkx6 transcription factors and ...... potent pancreatic progenitors.
@en
type
label
Nkx6 transcription factors and ...... potent pancreatic progenitors.
@ast
Nkx6 transcription factors and ...... potent pancreatic progenitors.
@en
prefLabel
Nkx6 transcription factors and ...... potent pancreatic progenitors.
@ast
Nkx6 transcription factors and ...... potent pancreatic progenitors.
@en
P2860
P1433
P1476
Nkx6 transcription factors and ...... ipotent pancreatic progenitors
@en
P2093
Maike Sander
Shelley B Nelson
P2860
P304
P356
10.1016/J.DEVCEL.2010.05.015
P407
P577
2010-06-01T00:00:00Z