Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
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The nuclear envelope: an intriguing focal point for neurogenetic diseaseNuclear migration events throughout developmentAltered nuclear dynamics in MDX myofibers.Novel nesprin-1 mutations associated with dilated cardiomyopathy cause nuclear envelope disruption and defects in myogenesis.Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscleDisruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.Cellular mechanosensing: getting to the nucleus of it all.Nesprins anchor kinesin-1 motors to the nucleus to drive nuclear distribution in muscle cells.Nuclear calcium in cardiac myocytes.Making the LINC: SUN and KASH protein interactions.Nesprin provides elastic properties to muscle nuclei by cooperating with spectraplakin and EB1.Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex.AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation.The mammalian LINC complex regulates genome transcriptional responses to substrate rigidityBlood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases.The nucleus is a conserved mechanosensation and mechanoresponse organelle.Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease.Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage.Mechanotransduction and nuclear function.The nuclear lamina in health and disease.Nesprin-1 role in DNA damage responseThe Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction.Nuclear envelopathies: a complex LINC between nuclear envelope and pathology.Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement.Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells.Luma is not essential for murine cardiac development and function.Cell mechanotransduction: Stretch to express.Decreased WNT/β-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a/C gene.Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathyNesprin-1 and nesprin-2 regulate endothelial cell shape and migrationThe Pathogenesis and Therapies of Striated Muscle LaminopathiesNesprins and Lamins in Health and Diseases of Cardiac and Skeletal Muscles
P2860
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P2860
Targeted ablation of nesprin 1 and nesprin 2 from murine myocardium results in cardiomyopathy, altered nuclear morphology and inhibition of the biomechanical gene response.
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2014 nî lūn-bûn
@nan
2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Targeted ablation of nesprin 1 ...... e biomechanical gene response.
@ast
Targeted ablation of nesprin 1 ...... e biomechanical gene response.
@en
type
label
Targeted ablation of nesprin 1 ...... e biomechanical gene response.
@ast
Targeted ablation of nesprin 1 ...... e biomechanical gene response.
@en
prefLabel
Targeted ablation of nesprin 1 ...... e biomechanical gene response.
@ast
Targeted ablation of nesprin 1 ...... e biomechanical gene response.
@en
P2093
P2860
P50
P1433
P1476
Targeted ablation of nesprin 1 ...... he biomechanical gene response
@en
P2093
Andrew McCulloch
Emily Pfeiffer
Indroneal Banerjee
Jianlin Zhang
Kunfu Ouyang
Kyle S Buchholz
Larry Gerace
Sylvia M Evans
P2860
P304
P356
10.1371/JOURNAL.PGEN.1004114
P577
2014-02-20T00:00:00Z