Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure. - sprookjes - yvandenbroek - TriplyDB

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.

http://www.wikidata.org/entity/Q35128295

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Role of bile acids in the regulation of the metabolic pathways Gut Microbiota and Nonalcoholic Fatty Liver Disease: Insights on Mechanism and Application of Metabolomics Bile acid metabolism and signaling Bile acids, obesity, and the metabolic syndrome Bile Acid Alters Male Mouse Fertility in Metabolic Syndrome Context Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism FXR is a molecular target for the effects of vertical sleeve gastrectomy Bile acid signaling in metabolic disease and drug therapy Farnesoid X receptor: from medicinal chemistry to clinical applications Involvement of SIK3 in glucose and lipid homeostasis in mice.Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.Sexually dimorphic effect of in vitro fertilization (IVF) on adult mouse fat and liver metabolomes Bile acid binding resin improves metabolic control through the induction of energy expenditure Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance Impact of nutrient excess and endothelial nitric oxide synthase on the plasma metabolite profile in mice.Distinct signatures of host-microbial meta-metabolome and gut microbiome in two C57BL/6 strains under high-fat diet.Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.Urine bile acids relate to glucose control in patients with type 2 diabetes mellitus and a body mass index below 30 kg/m2 Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease.Metabolic effects of cholecystectomy: gallbladder ablation increases basal metabolic rate through G-protein coupled bile acid receptor Gpbar1-dependent mechanisms in mice.Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity Bile diversion to the distal small intestine has comparable metabolic benefits to bariatric surgery.Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.Lactobacillus casei Shirota Supplementation Does Not Restore Gut Microbiota Composition and Gut Barrier in Metabolic Syndrome: A Randomized Pilot Study.Nuclear receptor variants in liver disease.Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor.Mouse betaine-homocysteine S-methyltransferase deficiency reduces body fat via increasing energy expenditure and impairing lipid synthesis and enhancing glucose oxidation in white adipose tissue Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids.Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.Dietary fat and gut microbiota interactions determine diet-induced obesity in mice.Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway.An Intestinal Farnesoid X Receptor-Ceramide Signaling Axis Modulates Hepatic Gluconeogenesis in Mice.Synthesis and biological evaluations of chalcones, flavones and chromenes as farnesoid x receptor (FXR) antagonists.Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease.

P2860

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P2860

Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.

http://www.wikidata.org/entity/Q35128295

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2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Lowering bile acid pool size w ...... gh reduced energy expenditure.

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Lowering bile acid pool size w ...... gh reduced energy expenditure.

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Lowering bile acid pool size w ...... gh reduced energy expenditure.

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Lowering bile acid pool size w ...... gh reduced energy expenditure.

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Lowering bile acid pool size w ...... gh reduced energy expenditure.

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JBC.M111.248203

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Journal of Biological Chemistry

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Lowering bile acid pool size w ...... gh reduced energy expenditure.

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Chikage Mataki

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Eri Arita

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Hiroshi Itoh

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Hiroyuki Sato

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Kohkichi Morimoto

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Mitsuhiro Watanabe

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Taichi Sugizaki

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Yasushi Horai

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Yusuke Tanigawara

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P2860

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis

Identification of membrane-type receptor for bile acids (M-BAR)

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

A G protein-coupled receptor responsive to bile acids

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

A simple method for the isolation and purification of total lipides from animal tissues

Endogenous bile acids are ligands for the nuclear receptor FXR/BAR

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26913-26920

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scholarly article

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10.1074/JBC.M111.248203

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30

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286

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Kristina Schoonjans

Sander M. Houten

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2011-06-01T00:00:00Z

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51183838

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21632533

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