Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
about
Sphingosine kinase 1 is a reliable prognostic factor and a novel therapeutic target for uterine cervical cancer.Metabolic profiling reveals sphingosine-1-phosphate kinase 2 and lyase as key targets of (phyto-) estrogen action in the breast cancer cell line MCF-7 and not in MCF-12ABiological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agentSphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain BarrierEffect of alkyl chain length on sphingosine kinase 2 selectivity.The impact of sphingosine kinase-1 in head and neck cancer.Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitroSphingosine kinase 1 in cancer.Bringing balance by force: live cell extrusion controls epithelial cell numbersTargeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.TGFβ-Mediated induction of SphK1 as a potential determinant in human MDA-MB-231 breast cancer cell bone metastasis.A sphingosine kinase inhibitor combined with temozolomide induces glioblastoma cell death through accumulation of dihydrosphingosine and dihydroceramide, endoplasmic reticulum stress and autophagyTargeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo.Dengue Virus-Induced Inflammation of the Endothelium and the Potential Roles of Sphingosine Kinase-1 and MicroRNAs.The impact of sphingosine kinase inhibitor-loaded nanoparticles on bioelectrical and biomechanical properties of cancer cells.Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer.Targeting survival pathways in chronic myeloid leukaemia stem cellsSphingosine kinase 1 in viral infections.Major apoptotic mechanisms and genes involved in apoptosis.Impact of acetylation on tumor metabolism.Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection.Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism.Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.Involvement of vacuolar H(+)-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720.The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism.Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells.Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats.Inhibition of dihydroceramide desaturase activity by the sphingosine kinase inhibitor SKI II.Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells.Sphingosine kinase: a key to solving the 'French Paradox'?D-Glucosamine-derived synthons for assembly of L-threo-sphingoid bases. Total synthesis of rhizochalinin C.Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1.FTY720 (Fingolimod) sensitizes hepatocellular carcinoma cells to sorafenib-mediated cytotoxicity.Sphingosine kinase 1 enables communication between melanoma cells and fibroblasts that provides a new link to metastasis.Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer.The sphingosine kinase 2 inhibitor ABC294640 inhibits cervical carcinoma cell growth.LRIG1 modulates aggressiveness of head and neck cancers by regulating EGFR-MAPK-SPHK1 signaling and extracellular matrix remodeling.New extracellular factors in glioblastoma multiforme development: neurotensin, growth differentiation factor-15, sphingosine-1-phosphate and cytomegalovirus infection.
P2860
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P2860
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@ast
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@en
type
label
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@ast
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@en
prefLabel
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@ast
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@en
P2093
P2860
P1433
P1476
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
@en
P2093
Nigel J Pyne
Robert Bittman
Susan Pyne
P2860
P304
P356
10.1158/0008-5472.CAN-11-2364
P407
P577
2011-09-22T00:00:00Z