Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2 - sprookjes - yvandenbroek - TriplyDB

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

http://www.wikidata.org/entity/Q33755206

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Sphingolipids: a potential molecular approach to treat allergic inflammation Emerging role of sphingosine-1-phosphate signaling in head and neck squamous cell carcinoma The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined Evolving concepts in cancer therapy through targeting sphingolipid metabolism Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy Characterization of isoenzyme-selective inhibitors of human sphingosine kinases Biological characterization of 3-(2-amino-ethyl)-5-[3-(4-butoxyl-phenyl)-propylidene]-thiazolidine-2,4-dione (K145) as a selective sphingosine kinase-2 inhibitor and anticancer agent Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity.Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors.Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors.Drugging sphingosine kinases.Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma.Effect of alkyl chain length on sphingosine kinase 2 selectivity.Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate.Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.Sphingolipid modulation of angiogenic factor expression in neuroblastoma.Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells.The Concise Guide to PHARMACOLOGY 2013/14: enzymes.The roles of sphingosine kinase 1 and 2 in regulating the metabolome and survival of prostate cancer cells.The impact of sphingosine kinase-1 in head and neck cancer.Re-configuration of sphingolipid metabolism by oncogenic transformation.Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget.A novel sphingosine kinase inhibitor induces autophagy in tumor cells.Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons.Antiestrogenic effects of the novel sphingosine kinase-2 inhibitor ABC294640 Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.Synthesis of amidomethyltrifluoroborates and their use in cross-coupling reactions Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond.Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; indications for novel therapeutics.Sphingosine-1-phosphate and immune regulation: trafficking and beyond Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis Cross-coupling of mesylated phenol derivatives with potassium ammonio- and amidomethyltrifluoroborates Apoptotic sphingolipid ceramide in cancer therapy.Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2 Antitumor activity of sphingosine kinase 2 inhibitor ABC294640 and sorafenib in hepatocellular carcinoma xenografts.

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Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

http://www.wikidata.org/entity/Q33755206

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2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Pharmacology and antitumor act ...... ibitor of sphingosine kinase-2

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Pharmacology and antitumor act ...... ibitor of sphingosine kinase-2

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Pharmacology and antitumor act ...... ibitor of sphingosine kinase-2

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JPET.109.163444

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Journal of Pharmacology and Experimental Therapeutics

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Pharmacology and antitumor act ...... ibitor of sphingosine kinase-2

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Cecelia L Green

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Charles D Smith

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John J Upson

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Kevin J French

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Lynn W Maines

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Peng Gao

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Staci N Keller

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Vladimir Beljanski

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Wenxue Wang

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Yan Zhuang

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P2860

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases

Molecular cloning and functional characterization of murine sphingosine kinase

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

Discovery and evaluation of inhibitors of human sphingosine kinase.

Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1.

Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells.

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129-139

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20061445

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