Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies
about
Combined RNAi-mediated suppression of Rictor and EGFR resulted in complete tumor regression in an orthotopic glioblastoma tumor modelFas Versatile Signaling and Beyond: Pivotal Role of Tyrosine Phosphorylation in Context-Dependent Signaling and DiseasesMultilayered polymer-coated carbon nanotubes to deliver dasatinib.Neutralizing the EGF receptor in glioblastoma cells stimulates cell migration by activating uPAR-initiated cell signaling.Nuclear EGFRvIII-STAT5b complex contributes to glioblastoma cell survival by direct activation of the Bcl-XL promoter.Interaction of Src and Alpha-V Integrin Regulates Fibroblast Migration and Modulates Lung Fibrosis in A Preclinical Model of Lung FibrosisA graphic method for identification of novel glioma related genes.Therapeutic targeting of SRC kinase in myofibroblast differentiation and pulmonary fibrosis.Lyn facilitates glioblastoma cell survival under conditions of nutrient deprivation by promoting autophagy.Src family kinases and paclitaxel sensitivity.Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251.Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcoholNovel treatment strategies for brain tumors and metastases.Src family kinases differentially influence glioma growth and motilityMir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact.Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution.Establishment of human iPSC-based models for the study and targeting of glioma initiating cellsSRC family kinases as novel therapeutic targets to treat breast cancer brain metastases.Remodeling the Vascular Microenvironment of Glioblastoma with α-Particles.Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation.Genomic analyses reveal broad impact of miR-137 on genes associated with malignant transformation and neuronal differentiation in glioblastoma cells.Bosutinib Therapy Ameliorates Lung Inflammation and Fibrosis in Experimental Silicosis.Role of tyrosine kinase inhibitors in the management of high-grade gliomas.Molecular targeted therapy in recurrent glioblastoma: current challenges and future directions.Aberrant signaling pathways in glioma.A combination of tyrosine kinase inhibitors, crizotinib and dasatinib for the treatment of glioblastoma multiforme.BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma.Bevacizumab in high-grade gliomas: past, present, and future.Reprogramming strategies for the establishment of novel human cancer models.Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma.Impact of the SRC inhibitor dasatinib on the metastatic phenotype of human prostate cancer cells.Syndecan-1 knockdown inhibits glioma cell proliferation and invasion by deregulating a c-src/FAK-associated signaling pathway.Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627).L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor.Dasatinib in recurrent glioblastoma: failure as a teacher.RELN signaling modulates glioblastoma growth and substrate-dependent migration.INSIDIA: A FIJI Macro Delivering High-Throughput and High-Content Spheroid Invasion Analysis.Phase I trial of dasatinib, lenalidomide, and temozolomide in children with relapsed or refractory central nervous system tumors.Src is the primary target of aripiprazole, an atypical antipsychotic drug, in its anti-tumor action.
P2860
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P2860
Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studies
description
2010 nî lūn-bûn
@nan
2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@ast
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@en
type
label
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@ast
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@en
prefLabel
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@ast
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@en
P2093
P2860
P1433
P1476
Targeting SRC in glioblastoma ...... ionale and preclinical studies
@en
P2093
Candece L Gladson
John de Groot
Manmeet S Ahluwalia
Wei Michael Liu
P2860
P304
P356
10.1016/J.CANLET.2010.08.014
P407
P577
2010-12-01T00:00:00Z