Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
about
CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machineryASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasionMultimeric and differential binding of CIN85/CD2AP with two atypical proline-rich sequences from CD2 and Cbl-b*P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.High-resolution crystal structure of spectrin SH3 domain fused with a proline-rich peptideLysozyme contamination facilitates crystallization of a heterotrimeric cortactin–Arg–lysozyme complexThe promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A proteinRas superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategiesAmplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancerSrc-dependent phosphorylation of ASAP1 regulates podosomes.High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patientsMolecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase ItchCharacterization of domain-peptide interaction interface: prediction of SH3 domain-mediated protein-protein interaction network in yeast by generic structure-based models.The SH3 domain of HS1 protein recognizes lysine-rich polyproline motifs.ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.An integrative in silico approach for discovering candidates for drug-targetable protein-protein interactions in interactome dataSynthetic ligands discovered by in vitro selection.ING proteins as potential anticancer drug targets.Cytoskeleton alterations in melanoma: aberrant expression of cortactin, an actin-binding adapter protein, correlates with melanocytic tumor progression.GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.Targeting SRC in glioblastoma tumors and brain metastases: rationale and preclinical studiesArfGAPs: key regulators for receptor sorting.Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma CellsADP-Ribosylation Factor 1 Regulates Proliferation, Migration, and Fusion in Early Stage of Osteoclast DifferentiationPrognostic significance of cortactin levels in head and neck squamous cell carcinoma: comparison with epidermal growth factor receptor statusLysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.Allosteric properties of PH domains in Arf regulatory proteins.ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cellsThe EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue.eIF5B increases ASAP1 expression to promote HCC proliferation and invasion.Mammalian son of sevenless Guanine nucleotide exchange factors: old concepts and new perspectives.Cortactin in cell migration and cancer at a glanceA systematic approach to the development of novel therapeutics for lung cancer using genomic analyses.STRIPAK complexes in cell signaling and cancer.The EGFR-GEP100-Arf6 pathway in breast cancer: Full invasiveness is not from the inside.Design of a bi-functional peptide for protein assays: observation of cortactin expression in human placenta.Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D.
P2860
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P248
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P2860
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@ast
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en-gb
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@nl
type
label
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@ast
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en-gb
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@nl
prefLabel
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@ast
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en-gb
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@nl
P2093
P2860
P3181
P356
P1476
Targeting AMAP1 and cortactin ...... cancer invasion and metastasis
@en
P2093
Ari Hashimoto
Atsuko Yamada
Chitose Oneyama
Eiji Ogawa
Harumi Hosaka
Hidenori Kobayashi
Hirofumi Nakano
Hiromi Wada
Hisataka Sabe
Ken-ichi Akagi
P2860
P304
P3181
P356
10.1073/PNAS.0509166103
P407
P577
2006-05-02T00:00:00Z