An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.
about
Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neuronsBotulinum neurotoxin serotype A specific cell-based potency assay to replace the mouse bioassayEnhanced neutralization potency of botulinum neurotoxin antibodies using a red blood cell-targeting fusion proteinSmall molecules showing significant protection of mice against botulinum neurotoxin serotype AEpitope targeting of tertiary protein structure enables target-guided synthesis of a potent in-cell inhibitor of botulinum neurotoxin.Novel Benzimidazole Inhibitors of Botulinum Neurotoxin/A Display Enzyme and Cell-Based Potency.Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype ABotulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chainNeutralization of botulinum neurotoxin by a human monoclonal antibody specific for the catalytic light chain.Botulinum neurotoxin devoid of receptor binding domain translocates active protease.Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation.Identification of broad-based HIV-1 protease inhibitors from combinatorial librariesToosendanin: synthesis of the AB-ring and investigations of its anti-botulinum properties (Part II).Effects of hydroxamate metalloendoprotease inhibitors on botulinum neurotoxin A poisoned mouse neuromuscular junctionsDesign, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactionsA high-throughput-compatible FRET-based platform for identification and characterization of botulinum neurotoxin light chain modulatorsDiscovery libraries targeting the major enzyme classes: the serine hydrolases.Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library.The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone PharmacophoreSymptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule.Small-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.High yield derivation of enriched glutamatergic neurons from suspension-cultured mouse ESCs for neurotoxicology researchBasic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.Novel application of stem cell-derived neurons to evaluate the time- and dose-dependent progression of excitotoxic injuryHigh-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitorsCapsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin aSynthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.Enhancing the Pharmacokinetic Properties of Botulinum Neurotoxin Serotype A Protease Inhibitors Through Rational DesignThe zinc-dependent protease activity of the botulinum neurotoxinsCleavage of SNAP25 and its shorter versions by the protease domain of serotype A botulinum neurotoxin.Functional evaluation of biological neurotoxins in networked cultures of stem cell-derived central nervous system neuronsDynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulismAccelerated intoxication of GABAergic synapses by botulinum neurotoxin A disinhibits stem cell-derived neuron networks prior to network silencing.Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism.Monoclonal Antibodies that Inhibit the Proteolytic Activity of Botulinum Neurotoxin Serotype/B.Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discoveryMicrosphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
P2860
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P2860
An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
An in vitro and in vivo discon ...... inum neurotoxin A antagonists.
@ast
An in vitro and in vivo discon ...... inum neurotoxin A antagonists.
@en
type
label
An in vitro and in vivo discon ...... inum neurotoxin A antagonists.
@ast
An in vitro and in vivo discon ...... inum neurotoxin A antagonists.
@en
prefLabel
An in vitro and in vivo discon ...... inum neurotoxin A antagonists.
@ast
An in vitro and in vivo discon ...... inum neurotoxin A antagonists.
@en
P2093
P2860
P356
P1476
An in vitro and in vivo discon ...... linum neurotoxin A antagonists
@en
P2093
Carl J Malizio
Colin M Clancy
Dale L Boger
Eric A Johnson
Joseph T Barbieri
Kim D Janda
Lisa M Eubanks
Mark S Hixon
Michael C Goodnough
Tobin J Dickerson
P2860
P304
P356
10.1073/PNAS.0611213104
P407
P577
2007-02-09T00:00:00Z