Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. - sprookjes - yvandenbroek - TriplyDB

Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.

Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.

http://www.wikidata.org/entity/Q35722236

about

The Emerging and Diverse Roles of Src-Like Adaptor Proteins in Health and Disease Role of SRC-like adaptor protein (SLAP) in immune and malignant cell signaling.SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.On-bead screening of combinatorial libraries: reduction of nonspecific binding by decreasing surface ligand density.SLAP deficiency decreases dsDNA autoantibody production Src-Like adaptor protein (SLAP) binds to the receptor tyrosine kinase Flt3 and modulates receptor stability and downstream signaling.SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.SLAP deficiency enhances number and function of regulatory T cells preventing chronic autoimmune arthritis in SKG mice.Ins (endocytosis) and outs (exocytosis) of GLUT4 trafficking Src-like adaptor protein regulates osteoclast generation and survival.Mechanism of upregulation of the inhibitory regulator, src-like adaptor protein (SLAP), by glucocorticoids in mast cells.Src-like adaptor protein (SLAP) is upregulated in antigen-stimulated mast cells and acts as a negative regulator.The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation SLAP deficiency increases TCR avidity leading to altered repertoire and negative selection of cognate antigen-specific CD8+ T cells.Activation of EphA receptors mediates the recruitment of the adaptor protein Slap, contributing to the downregulation of N-methyl-D-aspartate receptors.Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.

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Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner.

http://www.wikidata.org/entity/Q35722236

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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name

Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

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Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

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type

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Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

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Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

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Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

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Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

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PNAS.0608965103

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Proceedings of the National Academy of Sciences of the United States of America

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Src-like adaptor protein (SLAP ...... s in a c-Cbl-dependent manner.

@en

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Carmen White

http://www.w3.org/2001/XMLSchema#string

Hua Gu

http://www.w3.org/2001/XMLSchema#string

Leonard L Dragone

http://www.w3.org/2001/XMLSchema#string

Margaret D Myers

http://www.w3.org/2001/XMLSchema#string

Shyam Gadwal

http://www.w3.org/2001/XMLSchema#string

Tomasz Sosinowski

http://www.w3.org/2001/XMLSchema#string

P2860

Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase

Src-like adaptor protein (Slap) is a negative regulator of mitogenesis

Functional cooperation between c-Cbl and Src-like adaptor protein 2 in the negative regulation of T-cell receptor signaling.

SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor

The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

Slap negatively regulates Src mitogenic function but does not revert Src-induced cell morphology changes.

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18202-18207

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scholarly article

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10.1073/PNAS.0608965103

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48

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103

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2006-11-16T00:00:00Z

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6688316

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17110436

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1838730

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