Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
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NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivoThe crosstalk of mTOR/S6K1 and Hedgehog pathwaysA novel splice variant of GLI1 that promotes glioblastoma cell migration and invasionThe PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinomaThe hedgehog pathway in triple-negative breast cancerTherapeutic Targeting of TelomeraseDeciphering the role of hedgehog signaling in pancreatic cancerHedgehog signaling: modulation of cancer properies and tumor mircroenvironmentTargeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI InhibitorsTargeting the Hedgehog Pathway in Pediatric MedulloblastomaNon-Canonical Hh Signaling in Cancer-Current Understanding and Future DirectionsThe Role of Hedgehog Signaling in Tumor Induced Bone DiseaseCooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapyAberrant activation of the hedgehog signaling pathway in malignant hematological neoplasmsHedgehog signaling pathway in ovarian cancerContext-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapyInhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft modelSonic Hedgehog promotes tumor cell survival by inhibiting CDON pro-apoptotic activityRole of Akt signaling in resistance to DNA-targeted therapyMolecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cellsGli1 protein regulates the S-phase checkpoint in tumor cells via Bid protein, and its inhibition sensitizes to DNA topoisomerase 1 inhibitorsHedgehog signaling and the Gli code in stem cells, cancer, and metastasesCyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cellsA structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathwaysComputational prediction and experimental verification of new MAP kinase docking sites and substrates including Gli transcription factorsIrradiated riboflavin diminishes the aggressiveness of melanoma in vitro and in vivoSelf-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistanceGLI2-mediated melanoma invasion and metastasis.Targeting GLI1 expression in human inflammatory breast cancer cells enhances apoptosis and attenuates migration.A magnetic anti-cancer compound for magnet-guided delivery and magnetic resonance imaging.MMTV-Wnt1 and -DeltaN89beta-catenin induce canonical signaling in distinct progenitors and differentially activate Hedgehog signaling within mammary tumorsRecent patents for Hedgehog pathway inhibitors for the treatment of malignancy.Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival.GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcomaPDGFRα up-regulation mediated by sonic hedgehog pathway activation leads to BRAF inhibitor resistance in melanoma cells with BRAF mutation.Itraconazole exerts its anti-melanoma effect by suppressing Hedgehog, Wnt, and PI3K/mTOR signaling pathwaysCombined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia.
P2860
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P2860
Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Melanomas require HEDGEHOG-GLI ...... and the RAS-MEK/AKT pathways.
@ast
Melanomas require HEDGEHOG-GLI ...... and the RAS-MEK/AKT pathways.
@en
type
label
Melanomas require HEDGEHOG-GLI ...... and the RAS-MEK/AKT pathways.
@ast
Melanomas require HEDGEHOG-GLI ...... and the RAS-MEK/AKT pathways.
@en
prefLabel
Melanomas require HEDGEHOG-GLI ...... and the RAS-MEK/AKT pathways.
@ast
Melanomas require HEDGEHOG-GLI ...... and the RAS-MEK/AKT pathways.
@en
P2093
P2860
P356
P1476
Melanomas require HEDGEHOG-GLI ...... 1 and the RAS-MEK/AKT pathways
@en
P2093
Ariel Ruiz I Altaba
Friedrich Beermann
Marie Zbinden
Rafael Correa
Vincent Piguet
Virginie Clement
P2860
P304
P356
10.1073/PNAS.0700776104
P407
P577
2007-03-28T00:00:00Z