Blood-brain barrier transport of morphine in patients with severe brain trauma - sprookjes - yvandenbroek - TriplyDB

Blood-brain barrier transport of morphine in patients with severe brain trauma

Blood-brain barrier transport of morphine in patients with severe brain trauma

http://www.wikidata.org/entity/Q35826049

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Microdialysis versus other techniques for the clinical assessment of in vivo tissue drug distribution.Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.Cerebral uptake of drugs in humans.Clinical microdialysis in skin and soft tissues: an update.The mastermind approach to CNS drug therapy: translational prediction of human brain distribution, target site kinetics, and therapeutic effects.On the rate and extent of drug delivery to the brain.The influence of age on the distribution of morphine and morphine-3-glucuronide across the blood-brain barrier in sheep Utility of CSF in translational neuroscience.Translational aspects of blood-brain barrier transport and central nervous system effects of drugs: from discovery to patients.Aspects on the Physiological and Biochemical Foundations of Neurocritical Care Opioids in the treatment of restless legs syndrome: pharmacological and clinical aspects.An introduction to physiologically-based pharmacokinetic models.Natural Compounds as a Therapeutic Intervention following Traumatic Brain Injury: The Role of Phytochemicals.A Generic Multi-Compartmental CNS Distribution Model Structure for 9 Drugs Allows Prediction of Human Brain Target Site Concentrations Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain.Brain microdialysis study of meropenem in two patients with acute brain injury Microdialysate concentration changes do not provide sufficient information to evaluate metabolic effects of lactate supplementation in brain-injured patients Ventilatory responses of healthy subjects to intravenous combinations of morphine and oxycodone under imposed hypercapnic and hypoxaemic conditions Exploring new routes for neuroprotective drug development in traumatic brain injury.Development of a Region-Specific Physiologically Based Pharmacokinetic Brain Model to Assess Hippocampus and Frontal Cortex Pharmacokinetics.

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P2860

Blood-brain barrier transport of morphine in patients with severe brain trauma

http://www.wikidata.org/entity/Q35826049

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2004 nî lūn-bûn

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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2004年论文

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2004年论文

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name

Blood-brain barrier transport of morphine in patients with severe brain trauma

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Blood-brain barrier transport of morphine in patients with severe brain trauma

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Blood-brain barrier transport of morphine in patients with severe brain trauma

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Blood-brain barrier transport of morphine in patients with severe brain trauma

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Blood-brain barrier transport of morphine in patients with severe brain trauma

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Blood-brain barrier transport of morphine in patients with severe brain trauma

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J.1365-2125.2003.02032.X

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British Journal of Clinical Pharmacology

P1476

Blood-brain barrier transport of morphine in patients with severe brain trauma

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C Johan F Lundberg

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Carl-Henrik Nordström

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Karin Tunblad

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Margareta Hammarlund-Udenaes

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Per Ederoth

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René Bouw

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Urban Ungerstedt

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P2860

Morphine and metabolite behavior after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide

An improved method for the simultaneous determination of morphine and its principal glucuronide metabolites

Increased drug delivery to the brain by P-glycoprotein inhibition.

Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs.

Biochemical, cellular, and pharmacological aspects of the multidrug transporter.

Target-controlled infusion systems: role in anaesthesia and analgesia.

Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein.

Interstitial glycerol as a marker for membrane phospholipid degradation in the acutely injured human brain.

The multidrug resistance P-glycoprotein. Oligomeric state and intramolecular interactions.

The role of P-glycoprotein in blood-brain barrier transport of morphine: transcortical microdialysis studies in mdr1a (-/-) and mdr1a (+/+) mice.

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427-435

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blood–brain barrier

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