Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.
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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's diseaseRosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neuronsProteomic analysis of mitochondria in APOE transgenic mice and in response to an ischemic challengeApolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.Alzheimer disease models and human neuropathology: similarities and differencesApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice.ApoE isoform-specific regulation of regeneration in the peripheral nervous systemAPOE and neuroenergetics: an emerging paradigm in Alzheimer's disease.Kinesin molecular motors: transport pathways, receptors, and human disease.Mouse models of Alzheimer's disease: a quest for plaques and tangles.Apolipoprotein E: structure and function in lipid metabolism, neurobiology, and Alzheimer's diseases.Neuronal or glial expression of human apolipoprotein e4 affects parenchymal and vascular amyloid pathology differentially in different brain regions of double- and triple-transgenic miceInteractive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adultsIntroducing Human APOE into Aβ Transgenic Mouse Models.Cargo-carrying motor vehicles on the neuronal highway: transport pathways and neurodegenerative disease.Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy.Alteration of Golgi Structure by Stress: A Link to Neurodegeneration?Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.Studies of the central nervous system-derived CAD cell line, a suitable model for intraneuronal transport studies?PATHOLOGIES OF AXONAL TRANSPORT IN NEURODEGENERATIVE DISEASESNeuronal fiber bundle lengths in healthy adult carriers of the ApoE4 allele: a quantitative tractography DTI study.Motor impairment in Alzheimer's disease and transgenic Alzheimer's disease mouse models.Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation.Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptorsLinking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesisApolipoprotein E as a β-amyloid-independent factor in Alzheimer's disease.Axonal degeneration as a therapeutic target in the CNS.Axonal degeneration in Alzheimer's disease: when signaling abnormalities meet the axonal transport system.Deciphering the mechanism underlying late-onset Alzheimer disease.The dark sides of amyloid in Alzheimer's disease pathogenesis.The Complex Role of Apolipoprotein E in Alzheimer's Disease: an Overview and Update.Is abnormal axonal transport a cause, a contributing factor or a consequence of the neuronal pathology in Alzheimer's disease?Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc.Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease.Altered levels of cerebrospinal fluid reelin in frontotemporal dementia and Alzheimer's disease.Apolipoprotein E decreases tau kinases and phospho-tau levels in primary neurons.Roles of apolipoprotein E4 (ApoE4) in the pathogenesis of Alzheimer's disease: lessons from ApoE mouse models.Use-dependent dendritic regrowth is limited after unilateral controlled cortical impact to the forelimb sensorimotor cortex.Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease.
P2860
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P2860
Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@ast
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@en
type
label
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@ast
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@en
prefLabel
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@ast
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@en
P2093
P2860
P1476
Prominent axonopathy and disru ...... rons of brain and spinal cord.
@en
P2093
A Van Lommel
F Bronfman
F Van Leuven
J Van Dorpe
K Bruynseels
P2860
P304
P356
10.1016/S0002-9440(10)64788-8
P407
P577
2000-11-01T00:00:00Z