Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.
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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety AssessmentComputer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesComputational cardiology: how computer simulations could be used to develop new therapies and advance existing onesThe Cardiac Electrophysiology Web LabImages as drivers of progress in cardiac computational modelling.Late sodium current block for drug-induced long QT syndrome: Results from a prospective clinical trialVoltage and calcium dynamics both underlie cellular alternans in cardiac myocytes.Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study.Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells.Exercise training-induced bradycardia: evidence for enhanced parasympathetic regulation without changes in intrinsic sinoatrial node functionL-Type Calcium Channel Inhibition Contributes to the Proarrhythmic Effects of Aconitine in Human Cardiomyocytes.Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytesRapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytesGlutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion.The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart.Computational approaches to understand cardiac electrophysiology and arrhythmias.Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: a study to assess the drug's cardiac ion channel profileIn silico assessment of drug safety in human heart applied to late sodium current blockersBridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology.Cardiac Physiology of Aging: Extracellular Considerations.Induced pluripotent stem cells: at the heart of cardiovascular precision medicine.Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?Role of abnormal repolarization in the mechanism of cardiac arrhythmia.Frequency-dependent drug screening using optogenetic stimulation of human iPSC-derived cardiomyocytes.Ions, equations and electrons: the evolving role of computer simulations in cardiac electrophysiology safety evaluations.Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic CardiotoxicityIntracellular calcium and the mechanism of the dip in the anodal strength-interval curve in cardiac tissue.Computational cardiology: the heart of the matter.From Single Myocyte to Whole Heart: The Intricate Dance of Electrophysiology and Modeling.Potassium channels in the heart: structure, function and regulation.Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling.Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome.Quantifying inter-species differences in contractile function through biophysical modelling.Modelling the effects of chloroquine on KCNJ2-linked short QT syndrome.Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation.Mechanism of doxorubicin cardiotoxicity evaluated by integrating multiple molecular effects into a biophysical model.Divergent effect of adrenaline in human induced pluripotent stem cell derived cardiomyocytes obtained from hypertrophic cardiomyopathy.How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.Short-term action potential memory and electrical restitution: A cellular computational study on the stability of cardiac repolarization under dynamic pacing.Dynamical mechanisms of phase-2 early afterdepolarizations in human ventricular myocytes: insights from bifurcation analyses of two mathematical models.
P2860
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P2860
Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Quantitative comparison of car ...... in human and nonhuman species.
@ast
Quantitative comparison of car ...... in human and nonhuman species.
@en
type
label
Quantitative comparison of car ...... in human and nonhuman species.
@ast
Quantitative comparison of car ...... in human and nonhuman species.
@en
prefLabel
Quantitative comparison of car ...... in human and nonhuman species.
@ast
Quantitative comparison of car ...... in human and nonhuman species.
@en
P2860
P1476
Quantitative comparison of car ...... in human and nonhuman species
@en
P2093
Yoram Rudy
P2860
P304
P356
10.1152/AJPHEART.00785.2011
P577
2011-12-09T00:00:00Z