Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.

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Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.

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Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.

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Reduced Expression of EXTL2, a ...... Longer Heparan Sulfate Chains.

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Reduced Expression of EXTL2, a ...... Longer Heparan Sulfate Chains.

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Reduced Expression of EXTL2, a ...... Longer Heparan Sulfate Chains.

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Reduced Expression of EXTL2, a ...... Longer Heparan Sulfate Chains.

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Reduced Expression of EXTL2, a ...... Longer Heparan Sulfate Chains.

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Reduced Expression of EXTL2, a ...... Longer Heparan Sulfate Chains

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Kirankumar Katta

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Marion Kusche-Gullberg

http://www.w3.org/2001/XMLSchema#string

Mona Grønning

http://www.w3.org/2001/XMLSchema#string

Szymon Czajkowski

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Tabasum Imran

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P2860

The tumor suppressor EXT-like gene EXTL2 encodes an alpha1, 4-N-acetylhexosaminyltransferase that transfers N-acetylgalactosamine and N-acetylglucosamine to the common glycosaminoglycan-protein linkage region. The key enzyme for the chain initiation

The putative tumor suppressors EXT1 and EXT2 form a stable complex that accumulates in the Golgi apparatus and catalyzes the synthesis of heparan sulfate

In vitro polymerization of heparan sulfate backbone by the EXT proteins

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation

The EXT1/EXT2 tumor suppressors: catalytic activities and role in heparan sulfate biosynthesis.

Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis

Genetic heterogeneity in families with hereditary multiple exostoses

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

The exostosin family: proteins with many functions

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation

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scholarly article

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10.1074/JBC.M114.631754

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English

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290

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Marta Busse-Wicher

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2015-03-31T00:00:00Z

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25829497

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Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.

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P2860

P2860

Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.

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