Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis
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Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfaEnzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesisB4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycanIn vitro polymerization of heparan sulfate backbone by the EXT proteinsThe link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteinsHuman genetic disorders and knockout mice deficient in glycosaminoglycanHeparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostosesCrystal structure of an alpha 1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis2-O-Phosphorylation of Xylose and 6-O-Sulfation of Galactose in the Protein Linkage Region of Glycosaminoglycans Influence the Glucuronyltransferase-I Activity Involved in the Linkage Region SynthesisSpecificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesisA systems biology approach for the investigation of the heparin/heparan sulfate interactomeFunctional Requirements for Heparan Sulfate Biosynthesis in Morphogenesis and Nervous System Development in C. elegansMutations in EXTL3 Cause Neuro-immuno-skeletal Dysplasia Syndrome.Multiple osteochondromas: clinicopathological and genetic spectrum and suggestions for clinical management.Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains.Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development.Heparan sulfate containing unsubstituted glucosamine residues: biosynthesis and heparanase-inhibitory activity.Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine.A broad spectrum of genomic changes in latinamerican patients with EXT1/EXT2-CDGGene silencing of EXTL2 and EXTL3 as a substrate deprivation therapy for heparan sulphate storing mucopolysaccharidoses.D-glucuronyl C5-epimerase suppresses small-cell lung cancer cell proliferation in vitro and tumour growth in vivo.Of hedgehogs and hereditary bone tumors: re-examination of the pathogenesis of osteochondromas.Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.The glomerular basement membrane as a model system to study the bioactivity of heparan sulfate glycosaminoglycans.When sugars guide axons: insights from heparan sulphate proteoglycan mutants.The identification of candidate genes and SNP markers for classical bovine spongiform encephalopathy susceptibility.Heparan sulphate biosynthesis and disease.Heparan sulfate: a key regulator of embryonic stem cell fate.Heparan sulfate biosynthesis: regulation and variability.Human genetic disorders caused by mutations in genes encoding biosynthetic enzymes for sulfated glycosaminoglycansIdentification and characterization of three Drosophila melanogaster glucuronyltransferases responsible for the synthesis of the conserved glycosaminoglycan-protein linkage region of proteoglycans. Two novel homologs exhibit broad specificity towardGlycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation.Expanding the spectrum of skeletal dysplasia with immunodeficiency: a commentary on identification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia.A network of clinically and functionally relevant genes is involved in the reversion of the tumorigenic phenotype of MDA-MB-231 breast cancer cells after transfer of human chromosome 8.Insights into the reaction mechanism of 3-O-sulfotransferase through QM/MM calculations.Structural characterization of heparan sulfate and chondroitin sulfate of syndecan-1 purified from normal murine mammary gland epithelial cells. Common phosphorylation of xylose and differential sulfation of galactose in the protein linkage region tIdentification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia.Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones.Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate.
P2860
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P2860
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@ast
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@en
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@nl
type
label
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@ast
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@en
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@nl
prefLabel
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@ast
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@en
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@nl
P2093
P2860
P356
P1476
Human tumor suppressor EXT gen ...... sulfate/ heparin biosynthesis
@en
P2093
H Kitagawa
K Sugahara
M Kusche-Gullberg
P2860
P304
P356
10.1073/PNAS.131188498
P407
P577
2001-06-19T00:00:00Z