V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
about
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switchingB cell receptor editing in tolerance and autoimmunitySpontaneous autoimmunity in mice that carry an IghV partial transgene: a required arginine in VHCDR3.Secondary rearrangements and hypermutation generate sufficient B cell diversity to mount protective antiviral immunoglobulin responses.Immunoglobulin heavy chain variable region gene replacement As a mechanism for receptor revision in rheumatoid arthritis synovial tissue B lymphocytesReceptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.Receptor selection in B and T lymphocytes.Revising B cell receptorsRAG-dependent peripheral T cell receptor diversification in CD8+ T lymphocytesLight chain inclusion permits terminal B cell differentiation and does not necessarily result in autoreactivity.Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanismInflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansionImmunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production.Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouseSomatic mutation and light chain rearrangement generate autoimmunity in anti-single-stranded DNA transgenic MRL/lpr mice.Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomasAntigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice.Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo.B cell receptor revision diminishes the autoreactive B cell response after antigen activation in miceInduction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.Differential accessibility at the kappa chain locus plays a role in allelic exclusion.Induction of light chain replacement in human plasma cells by caffeine is independent from both the upregulation of RAG protein expression and germ line transcription.Secondary mechanisms of diversification in the human antibody repertoire.Differential expression patterns of recombination-activating genes in individual mature B cells in juvenile idiopathic arthritis.Indications for peripheral light-chain revision and somatic hypermutation without a functional B-cell receptor in precursors of a composite diffuse large B-cell and Hodgkin's lymphoma.Stimulation of antiviral antibody response in SHIV-IIIB-infected macaques.Internalization of B cell receptors in human EU12 μHC⁺ immature B cells specifically alters downstream signaling events.Insights into the regulation of immunoglobulin light chain gene rearrangements via analysis of the kappa light chain locus in lambda myeloma.Recombination activating genes (RAG) induce secondary Ig gene rearrangement in and subsequent apoptosis of human peripheral blood circulating B lymphocytes.Genetic analysis of the maternally induced affinity enhancement in the non-Ox1 idiotypic antibody repertoire of the primary immune response to 2-phenyloxazolone.Antibody repertoire development in fetal and neonatal piglets. XXII. λ Rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine.Receptor revision plays no major role in shaping the receptor repertoire of human memory B cells after the onset of somatic hypermutation.Hereditary stability and variation in evolution and development.Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus.Burnet's unhappy hybridDeveloping B-cell theoriesContinued RAG expression in late stages of B cell development and no apparent re-induction after immunizion
P2860
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P2860
V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
V(D)J recombinase induction in ...... by antigen-receptor signalling
@ast
V(D)J recombinase induction in ...... by antigen-receptor signalling
@en
type
label
V(D)J recombinase induction in ...... by antigen-receptor signalling
@ast
V(D)J recombinase induction in ...... by antigen-receptor signalling
@en
prefLabel
V(D)J recombinase induction in ...... by antigen-receptor signalling
@ast
V(D)J recombinase induction in ...... by antigen-receptor signalling
@en
P2093
P2860
P356
P1433
P1476
V(D)J recombinase induction in ...... by antigen-receptor signalling
@en
P2093
P2860
P2888
P304
P356
10.1038/28419
P407
P577
1998-07-01T00:00:00Z
P6179
1042700812