Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins
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Human TRiC complex purified from HeLa cells contains all eight CCT subunits and is active in vitroContribution of the Type II Chaperonin, TRiC/CCT, to OncogenesisIdentification and functional analysis of healing regulators in Drosophila4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangementCrystal Structures of a Group II Chaperonin Reveal the Open and Closed States Associated with the Protein Folding CycleDual Action of ATP Hydrolysis Couples Lid Closure to Substrate Release into the Group II Chaperonin ChamberThe Crystal Structures of the Eukaryotic Chaperonin CCT Reveal Its Functional PartitioningThe molecular architecture of the eukaryotic chaperonin TRiC/CCTDynamics, flexibility, and allostery in molecular chaperoninsCCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cellsThe structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCTChaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomesStructure of the human TRiC/CCT Subunit 5 associated with hereditary sensory neuropathy.Action of the chaperonin GroEL/ES on a non-native substrate observed with single-molecule FRET.Decoded calreticulin-deficient embryonic stem cell transcriptome resolves latent cardiophenotype.Modulation of STAT3 folding and function by TRiC/CCT chaperonin.Subunit order of eukaryotic TRiC/CCT chaperonin by cross-linking, mass spectrometry, and combinatorial homology modeling.Structural Basis for Modulation of Quality Control Fate in a Marginally Stable Protein.Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins.Characterization of CCTα and evaluating its expression in the mud crab Scylla paramamosain when challenged by low temperatures alone and in combination with high and low salinity.A novel function of the monomeric CCTε subunit connects the serum response factor pathway to chaperone-mediated actin foldingLineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.Folding of large multidomain proteins by partial encapsulation in the chaperonin TRiC/CCT.Do chaperonins boost protein yields by accelerating folding or preventing aggregation?A gradient of ATP affinities generates an asymmetric power stroke driving the chaperonin TRIC/CCT folding cycle.Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO.Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCTPeroxisome degradation in mammals: mechanisms of action, recent advances, and perspectivesHuman CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.TRiC's tricks inhibit huntingtin aggregation.Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions.Development of free-energy-based models for chaperonin containing TCP-1 mediated folding of actin.Multiple states of a nucleotide-bound group 2 chaperonin.Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch.Controlling the cortical actin motor.TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells.Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.Insights into the intra-ring subunit order of TRiC/CCT: a structural and evolutionary analysis.Chaperonin containing TCP1 subunit 5 is a tumor associated antigen of non-small cell lung cancer.The Upf factor complex interacts with aberrant products derived from mRNAs containing a premature termination codon and facilitates their proteasomal degradation.
P2860
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P2860
Identification of the TRiC/CCT substrate binding sites uncovers the function of subunit diversity in eukaryotic chaperonins
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@ast
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@en
type
label
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@ast
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@en
prefLabel
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@ast
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@en
P2860
P50
P1433
P1476
Identification of the TRiC/CCT ...... sity in eukaryotic chaperonins
@en
P2093
Erik J Miller
Judith Frydman
P2860
P356
10.1016/J.MOLCEL.2006.09.003
P577
2006-10-01T00:00:00Z