Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade.
about
The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potencyIncreased response to glutamate in small diameter dorsal root ganglion neurons after sciatic nerve injuryAllosteric modulation of metabotropic glutamate receptors.Targeting glutamate synapses in schizophreniaLoss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.Targeting metabotropic glutamate receptors for novel treatments of schizophrenia.Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.Development of allosteric modulators of GPCRs for treatment of CNS disordersFunctional interaction of mGlu5 and NMDA receptors in aversive learning in rats.Pharmacological enhancement of memory and executive functioning in laboratory animals.Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders.mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration.mGluR5 positive allosteric modulation and its effects on MK-801 induced set-shifting impairments in a rat operant delayed matching/non-matching-to-sample taskMetabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.Acute administration of MK-801 in an animal model of psychosis in rats interferes with cognitively demanding forms of behavioral flexibility on a rotating arena.Selective remediation of reversal learning deficits in the neurodevelopmental MAM model of schizophrenia by a novel mGlu5 positive allosteric modulator.The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in RatsmGluR5 Positive and Negative Allosteric Modulators Differentially Affect Dendritic Spine Density and Morphology in the Prefrontal CortexProgress toward positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).Translational Concepts of mGluR5 in Synaptic Diseases of the BrainAcute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine.Autism spectrum disorder causes, mechanisms, and treatments: focus on neuronal synapses.Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential.Metabotropic glutamate receptors as therapeutic targets for schizophrenia.Glutamatergic transmission in schizophrenia: from basic research to clinical practiceLeading compounds for the validation of animal models of psychopathology.N-Acetylcysteine and metabotropic glutamate receptors: implications for the treatment of schizophrenia: a literature review.Impact of anxiety on prefrontal cortex encoding of cognitive flexibility.The mGluR5 positive allosteric modulator CDPPB inhibits SO₂-induced protein radical formation and mitochondrial dysfunction through activation of Akt in mouse hippocampal HT22 cells.Effects of D- and L-govadine on the disruption of touchscreen object-location paired associates learning in rats by acute MK-801 treatment.Allosteric Modulation of GPCRs: New Insights and Potential Utility for Treatment of Schizophrenia and Other CNS Disorders.Beyond dopamine: glutamate as a target for future antipsychotics.MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs.Glutamatergic antipsychotic drugs: a new dawn in the treatment of schizophrenia?In vivo positron emission tomography imaging with [¹¹C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons.Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning.Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.Effect of alpha7 nicotinic acetylcholine receptor agonists on attentional set-shifting impairment in rats.Role of mGlu5 Receptors and Inhibitory Neurotransmission in M1 Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.
P2860
Q21262024-B826929B-EE50-4660-BF9C-3B241CCC7ED9Q27336070-4D4265B4-6858-4D5E-9436-5376F4164DBAQ30448534-C6C2C379-93DC-4FC0-8D34-9AB52C299D41Q30460392-AB6E2AAB-E3CE-4D1F-ACCE-376667C6B390Q30498430-561DC295-71ED-47E3-A70A-A94415DCFF75Q30595720-E83654DB-B693-4B56-BB46-287F296846CEQ33604654-5FD0440F-4D3B-4D6B-8E48-B4E0366A6B02Q34068897-79D29DC8-0510-4A83-9D70-D82AFE3BAB21Q34373958-B3088837-370F-4E3D-8C81-EAA0522F8045Q34572032-CD04A3F0-C5B6-4962-846F-B3D8E45655C5Q34661221-24759FF8-4002-4CA2-ABAD-07C888151461Q34761363-7B9053A0-BDCD-48D9-AF56-72FC590CFE26Q34775016-BB2DCEAF-C433-4018-A11C-27230D4B8992Q34785084-CD80296E-6DAA-4835-AD69-174A7893F171Q35065682-64AF2CBE-1E91-4827-8302-F9ED43AC694DQ35238605-C5802D43-A9AD-4944-A680-5A3930E63C94Q35760205-A39480E3-258A-489D-969F-272E028406E6Q35833718-B2D7DCCC-138E-4069-9D99-B59525697024Q35867117-E3A90EF7-E4B1-4D8C-BC36-08ECF212DDEDQ36015452-1DF901BF-7CCD-44F4-897F-BE055D0B2AC5Q36424785-A4AAA69B-CE1C-4FDB-8F2B-89181092F3EFQ36883052-93A2A5FF-E0CE-4377-9C12-EC5A005FD430Q37068738-DBF870FA-DACC-4669-9039-F8DCA10CA99DQ37773480-5591A911-7AC9-4488-852A-F991833E3CB6Q37881198-82A25511-BE8C-406C-A42E-C77D2F98750EQ37980657-5332862C-F204-4ECD-B5F5-E8F5C3BC1419Q38128733-029E8199-B038-4B60-9A58-39909CC4C71CQ38175882-BA1A93AA-D001-4DDE-BC79-AE33222B20D7Q38851545-605E3861-866E-439E-9C84-05720B9A2FA7Q38924641-13B0DFAB-201B-4FFB-A045-333E291DF1BDQ38965146-B0F94D1E-43DA-4F44-89E5-8473FAE4E03CQ39284158-0EA196B4-8861-49CD-BDF3-56AD95825EC5Q39580232-F635E72A-F99E-481D-BBA0-4CEFA9A73262Q41456540-924B3D08-7200-4CF1-AF9C-31A298AE8A1CQ42544021-22CC2C0B-2A84-4D16-A54E-6A30802982E5Q42734765-46F456B1-C90F-48E8-AFF1-01B4022F718FQ43082537-4B28A4C2-8628-4916-AF21-5DC946BD3256Q45348307-DA475B7F-1FA3-4665-B311-DA00CFCC3B81Q46490757-678C351B-51FB-4DD6-8CA6-08ADC15F5F1EQ47836225-62FA8951-2F26-4BD7-AC73-8CD2D75F07DB
P2860
Activation of type 5 metabotropic glutamate receptors attenuates deficits in cognitive flexibility induced by NMDA receptor blockade.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@ast
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@en
type
label
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@ast
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@en
prefLabel
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@ast
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@en
P2860
P1476
Activation of type 5 metabotro ...... ced by NMDA receptor blockade.
@en
P2093
Mark R Stefani
P2860
P356
10.1016/J.EJPHAR.2010.01.028
P407
P577
2010-04-02T00:00:00Z