Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.
about
EARP is a multisubunit tethering complex involved in endocytic recyclingStructural and Functional Characterization of Cargo-Binding Sites on the μ4-Subunit of Adaptor Protein Complex 4Multiplex assay for live-cell monitoring of cellular fates of amyloid-β precursor protein (APP)Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent AutophagyThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production.The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function.Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Cargo recognition in clathrin-mediated endocytosisHigh Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer's disease amyloid plaquesSignificance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus.Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production.Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production.Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking.Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation.Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells.Intracellular itinerary of internalised β-secretase, BACE1, and its potential impact on β-amyloid peptide biogenesis.Retromer regulates postendocytic sorting of β-secretase in polarized Madin-Darby canine kidney cells.Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processingSnapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons.GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates Aβ production.The physical approximation of APP and BACE-1: A key event in alzheimer's disease pathogenesis.Interplay Between the Autophagy-Lysosomal Pathway and the Ubiquitin-Proteasome System: A Target for Therapeutic Development in Alzheimer's Disease.
P2860
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P2860
Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Adaptor protein 2-mediated end ...... precursor protein processing.
@ast
Adaptor protein 2-mediated end ...... precursor protein processing.
@en
type
label
Adaptor protein 2-mediated end ...... precursor protein processing.
@ast
Adaptor protein 2-mediated end ...... precursor protein processing.
@en
prefLabel
Adaptor protein 2-mediated end ...... precursor protein processing.
@ast
Adaptor protein 2-mediated end ...... precursor protein processing.
@en
P2093
P2860
P356
P1476
Adaptor protein 2-mediated end ...... d precursor protein processing
@en
P2093
Christina Schindler
Ginny G Farías
Javier G Magadán
Patricia V Burgos
Yogikala Prabhu
P2860
P304
P356
10.1091/MBC.E11-11-0944
P577
2012-05-02T00:00:00Z