Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.
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Heterologous ("nonspecific") and sex-differential effects of vaccines: epidemiology, clinical trials, and emerging immunologic mechanismsRole of innate immunity in neonatal infectionOntogeny of early life immunityA clear and present danger: inflammasomes DAMPing down disorders of pregnancyImmune response to vaccine adjuvants during the first year of lifeStructure-Based Design of Novel Human Toll-like Receptor 8 AgonistsNeonatal Vaccination: Challenges and Intervention StrategiesVirtual Screening Approaches towards the Discovery of Toll-Like Receptor ModulatorsImplications of Age-Dependent Immune Responses to Enterovirus 71 Infection for Disease Pathogenesis and Vaccine Design.Enrichment assessment of multiple virtual screening strategies for Toll-like receptor 8 agonists based on a maximal unbiased benchmarking data set.Rapid proliferation and differentiation impairs the development of memory CD8+ T cells in early life.Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes.Targeting regulatory T cells to improve vaccine immunogenicity in early life.Human Toll-like receptor 8-selective agonistic activities in 1-alkyl-1H-benzimidazol-2-aminesSoluble mediators regulating immunity in early lifeThe ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes.Decreased pattern recognition receptor signaling, interferon-signature, and bactericidal/permeability-increasing protein gene expression in cord blood of term low birth weight human newborns.Base modification strategies to modulate immune stimulation by an siRNA.The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly.Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice.In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant.Soluble ecto-5'-nucleotidase (5'-NT), alkaline phosphatase, and adenosine deaminase (ADA1) activities in neonatal blood favor elevated extracellular adenosine.Neonatal monocytes exhibit a unique histone modification landscape.Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures.An Immunological Perspective on Neonatal Sepsis.A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity.Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine.Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndromeTLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth.Vaccines against respiratory viral pathogens for use in neonates: opportunities and challenges.Postnatal Innate Immune Development: From Birth to Adulthood.Waning Immunity and Microbial Vaccines-Workshop of the National Institute of Allergy and Infectious Diseases.Unique aspects of the perinatal immune system.Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses.Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns.Prospective study of the innate cellular immune response in low vaccine responder children.Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization.Impaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytesThe TLR-specific adjuvants R-848 and CpG-B endorse the immunological reaction of neonatal antigen-presenting cells.
P2860
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P2860
Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@ast
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@en
type
label
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@ast
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@en
prefLabel
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@ast
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@en
P2093
P2860
P1476
Imidazoquinoline Toll-like rec ...... caspase-1-dependent pathways.
@en
P2093
Ariel Shuckett
David J Dowling
Eugénie E Suter
Guadalupe Cortés
Keith Mansfield
Kevin W Chi
Leighanne C Gallington
Liat Stoler-Barak
Mark Tomai
P2860
P304
195-204.e9
P356
10.1016/J.JACI.2012.02.042
P407
P577
2012-04-21T00:00:00Z