Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
about
Farnesyl transferase inhibitor resistance probed by target mutagenesisChemo-Immunotherapeutic Antimalarials Targeting Isoprenoid BiosynthesisGlobal proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogueIdentification of a novel class of farnesylation targets by structure-based modeling of binding specificity.Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme dataIn vitro selection of Plasmodium falciparum drug-resistant parasite lines.A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blottingTherapeutic intervention based on protein prenylation and associated modificationsAn essential farnesylated kinesin in Trypanosoma brucei.Acylation in trypanosomatids: an essential process and potential drug targetCurrent therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.Mechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.Three-dimensional structures in the design of therapeutics targeting parasitic protozoa: reflections on the past, present and future.Protein geranylgeranyltransferase-I of Trypanosoma cruzi.2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarialsIsoprenoid biosynthesis inhibition disrupts Rab5 localization and food vacuolar integrity in Plasmodium falciparum.Mechanisms of Chromosome Congression during Mitosis.Isoprenoid biosynthesis in Plasmodium falciparum.Farnesyl diphosphate analogues with omega-bioorthogonal azide and alkyne functional groups for protein farnesyl transferase-catalyzed ligation reactions.The Prenylated Proteome of Plasmodium falciparum Reveals Pathogen-specific Prenylation Activity and Drug Mechanism-of-action.Tackling resistance: emerging antimalarials and new parasite targets in the era of elimination
P2860
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P2860
Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Protein farnesyl transferase i ...... a and African trypanosomiasis.
@ast
Protein farnesyl transferase i ...... a and African trypanosomiasis.
@en
type
label
Protein farnesyl transferase i ...... a and African trypanosomiasis.
@ast
Protein farnesyl transferase i ...... a and African trypanosomiasis.
@en
prefLabel
Protein farnesyl transferase i ...... a and African trypanosomiasis.
@ast
Protein farnesyl transferase i ...... a and African trypanosomiasis.
@en
P2093
P921
P1476
Protein farnesyl transferase i ...... ia and African trypanosomiasis
@en
P2093
Frederick S Buckner
Kohei Yokoyama
Richard T Eastman
Wesley C Van Voorhis
P304
P577
2005-08-01T00:00:00Z