Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)
about
Biology of the major facilitative folate transporters SLC19A1 and SLC46A1Mapping membrane protein backbone dynamics: a comparison of site-directed spin labeling with NMR 15N-relaxation measurements.Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter.The proton-coupled folate transporter: physiological and pharmacological roles.Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins.The human proton-coupled folate transporter: Biology and therapeutic applications to cancer.The intestinal absorption of folates.Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6CSF 5-Methyltetrahydrofolate Serial Monitoring to Guide Treatment of Congenital Folate Malabsorption Due to Proton-Coupled Folate Transporter (PCFT) DeficiencyIdentification of Tyr residues that enhance folate substrate binding and constrain oscillation of the proton-coupled folate transporter (PCFT-SLC46A1).Identification of an Extracellular Gate for the Proton-coupled Folate Transporter (PCFT-SLC46A1) by Cysteine Cross-linking.Role of the fourth transmembrane domain in proton-coupled folate transporter function as assessed by the substituted cysteine accessibility method.Role of the tryptophan residues in proton-coupled folate transporter (PCFT-SLC46A1) function.Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker.The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.Residues in the eighth transmembrane domain of the proton-coupled folate transporter (SLC46A1) play an important role in defining the aqueous translocation pathway and in folate substrate binding.Impact of posttranslational modifications of engineered cysteines on the substituted cysteine accessibility method: evidence for glutathionylation.The proton-coupled folate transporter (PCFT-SLC46A1) and the syndrome of systemic and cerebral folate deficiency of infancy: Hereditary folate malabsorption.Experimentally optimized threading structures of the proton-coupled folate transporter.The monomeric state of the proton-coupled folate transporter represents the functional unit in the plasma membrane.The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer.
P2860
Q26998717-6EC298B7-C896-4EEA-9E0C-BA5EB6E4CC06Q30303139-8F39A7D9-8361-456B-9139-8798D6B5009BQ30365011-1645550B-CBA5-43F4-A748-9B2F0EA7DE19Q33908502-25B74C57-79E7-4143-BA42-DD8270D28AD7Q34131175-DF452561-DE80-490B-B4E1-E9C2079CDB34Q34297931-BD2F2034-D46A-43B6-A3D8-710DD012A084Q34403349-EB820E20-4208-48C8-9071-5C1B4E885DCEQ34471848-FC43C7C4-5EF1-4357-B29F-1849BB255B8FQ34477752-CF7ED782-20F1-4E44-BFB3-50261F2DD12CQ35437120-AA3D581B-4645-428D-92BD-8C9C9DE8CD82Q36778842-B6DF1369-2748-46A5-BC81-A1DA432FDBB3Q36923565-9949C4B4-975F-44A3-B90C-A5F504267C35Q37139378-1637CFFF-F9F1-472A-9138-16632856DEA5Q37546123-33A3174F-1290-4467-B518-C55E4B541D7EQ37663377-AE54DE78-CAA3-4C87-B067-2ED83C4D03C4Q38627498-BBB516AD-A971-436C-8D0A-697D148048FDQ38719435-495CFB32-C37D-43E9-8FEC-AC88877E6F83Q38963604-A50B4CE1-B135-4689-83E4-FC3C49B7C230Q39065236-22020EB3-9449-4E92-A53A-E0CAD1996576Q48626485-2DC1393A-B0F0-498D-B55F-D4004FF6F516Q50062142-F60735D1-A9D9-4F44-8007-76280DFD2C15
P2860
Identification of a functionally critical GXXG motif and its relationship to the folate binding site of the proton-coupled folate transporter (PCFT-SLC46A1)
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@ast
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@en
type
label
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@ast
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@en
prefLabel
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@ast
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@en
P2093
P2860
P1476
Identification of a functional ...... ate transporter (PCFT-SLC46A1)
@en
P2093
Daniel Sanghoon Shin
I David Goldman
Rongbao Zhao
P2860
P304
P356
10.1152/AJPCELL.00123.2012
P50
P577
2012-07-11T00:00:00Z