Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.
about
Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: the Chediak-Higashi syndromeMolecular mechanism and cellular function of MHCII ubiquitinationProteases involved in MHC class II antigen presentationInvariant chain made in Escherichia coli has an exposed N-terminal segment that blocks antigen binding to HLA-DR1 and a trimeric C-terminal segment that binds empty HLA-DR1Helper T cell epitope-mapping reveals MHC-peptide binding affinities that correlate with T helper cell responses to pneumococcal surface protein A.Truncation of the class II beta-chain cytoplasmic domain influences the level of class II/invariant chain-derived peptide complexes.Phagocytic antigen processing and effects of microbial products on antigen processing and T-cell responses.Intracellular traffic to compartments for MHC class II peptide loading: signals for endosomal and polarized sorting.Intracellular transport and peptide loading of MHC class II molecules: regulation by chaperones and motors.Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartmentsInteraction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) regionThe cytoplasmic tail of invariant chain regulates endosome fusion and morphologyCathepsin L is essential for onset of autoimmune diabetes in NOD mice.Phagocytic processing of antigens for presentation by class II major histocompatibility complex molecules.Antigen traffic pathways in dendritic cells.Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM.The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.Quantitating MHC class II trafficking in primary dendritic cells using imaging flow cytometryIsoforms of the invariant chain regulate transport of MHC class II molecules to antigen processing compartmentsAggregation as a determinant of protein fate in post-Golgi compartments: role of the luminal domain of furin in lysosomal targetingAsparaginyl endopeptidase: case history of a class II MHC compartment protease.Ii chain controls the transport of major histocompatibility complex class II molecules to and from lysosomes.Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells.COOH-terminal truncations promote proteasome-dependent degradation of mature cystic fibrosis transmembrane conductance regulator from post-Golgi compartments.Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes.Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation.Degradation of mouse invariant chain: roles of cathepsins S and D and the influence of major histocompatibility complex polymorphismDelivery of B cell receptor-internalized antigen to endosomes and class II vesiclesType II and III receptors for immunoglobulin G (IgG) control the presentation of different T cell epitopes from single IgG-complexed antigens.Exogenously provided peptides of a self-antigen can be processed into forms that are recognized by self-T cells.Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal.Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.The MHC class II-associated invariant chain interacts with the neonatal Fc gamma receptor and modulates its trafficking to endosomal/lysosomal compartments.Exposing the Specific Roles of the Invariant Chain Isoforms in Shaping the MHC Class II Peptidome.MHC class II antigen presentation by dendritic cells regulated through endosomal sorting.Association of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loading.Human phagosome processing of Mycobacterium tuberculosis antigens is modulated by interferon-γ and interleukin-10.Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments.Introducing endogenous antigens into the major histocompatibility complex (MHC) class II presentation pathway. Both Ii mediated inhibition and enhancement of endogenous peptide/MHC class II presentation require the same Ii domains.A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules.
P2860
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P2860
Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh
1995年學術文章
@zh-hant
name
Invariant chain cleavage and p ...... ity complex class II vesicles.
@ast
Invariant chain cleavage and p ...... ity complex class II vesicles.
@en
type
label
Invariant chain cleavage and p ...... ity complex class II vesicles.
@ast
Invariant chain cleavage and p ...... ity complex class II vesicles.
@en
prefLabel
Invariant chain cleavage and p ...... ity complex class II vesicles.
@ast
Invariant chain cleavage and p ...... ity complex class II vesicles.
@en
P2093
P2860
P356
P1476
Invariant chain cleavage and p ...... ity complex class II vesicles.
@en
P2093
P2860
P304
P356
10.1084/JEM.181.5.1729
P407
P577
1995-05-01T00:00:00Z