Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.
about
Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) responseValidating viral quasispecies with digital organisms: a re-examination of the critical mutation rateInefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivoRole of HLA Adaptation in HIV EvolutionMechanisms of HIV protein degradation into epitopes: implications for vaccine designMolecular Clocks and the Puzzle of RNA Virus OriginsCellular immune responses against hepatitis C virus: the evidence base 2002Mutational escape from CD8+ T cell immunity: HCV evolution, from chimpanzees to manLoss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27–restricted human immune responsePrevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell DeterminantMutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infectionsGenetics of susceptibility to human infectious diseaseEfficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B 2705-restricted CD8+ T cellsAdaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.Defining epitope coverage requirements for T cell-based HIV vaccines: theoretical considerations and practical applications.Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.Modelling the evolution and spread of HIV immune escape mutantsEstimating Costs and Benefits of CTL Escape Mutations in SIV/HIV Infection.Adaptation to different human populations by HIV-1 revealed by codon-based analysesSequential broadening of CTL responses in early HIV-1 infection is associated with viral escape.Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.Molecular evolution of human immunodeficiency virus type 1 upon transmission between human leukocyte antigen disparate donor-recipient pairs.Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus.Dynamics of immune escape during HIV/SIV infection.Abundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression.Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.Frequent toggling between alternative amino acids is driven by selection in HIV-1HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infectionAdaptive changes in HIV-1 subtype C proteins during early infection are driven by changes in HLA-associated immune pressure.Within-Epitope Interactions Can Bias CTL Escape Estimation in Early HIV InfectionFunctional avidity and IL-2/perforin production is linked to the emergence of mutations within HLA-B*5701-restricted epitopes and HIV-1 disease progressionHuman immunodeficiency virus (HIV)-specific gamma interferon secretion directed against all expressed HIV genes: relationship to rate of CD4 decline.The majority of currently circulating human immunodeficiency virus type 1 clade B viruses fail to prime cytotoxic T-lymphocyte responses against an otherwise immunodominant HLA-A2-restricted epitope: implications for vaccine design.Immunologic pressure within class I-restricted cognate human immunodeficiency virus epitopes during highly active antiretroviral therapyQuantifying the impact of human immunodeficiency virus-1 escape from cytotoxic T-lymphocytes.Rapid viral escape at an immunodominant simian-human immunodeficiency virus cytotoxic T-lymphocyte epitope exacts a dramatic fitness costHIV-1 Transmission, Replication Fitness and Disease Progression.Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity
P2860
Q21131580-43D32E5B-EE63-4AF9-A03C-07CD42E8502BQ24795230-1FB34605-BDEC-4281-8335-37EF23969C93Q25255777-48CD17E0-4FC1-4B2F-9B89-5663CF3F7CCAQ26772713-AE560CBF-874E-4BE9-8896-7F806072B51DQ26866505-D89E67AF-5994-49F9-8B0E-312293583E61Q27473380-00D7CFDA-7674-4587-8C34-04A6E37C8499Q27480725-7D54EEB3-A867-4467-A4E6-511FAC1363FEQ27485215-39797296-3FDA-4915-A5B4-45E788698123Q27487784-58C02A5B-902B-4FDB-970E-ED2770A00851Q27652640-1EC8794F-658E-4357-B6B5-0874F9A39508Q28086907-96D02C72-F3B9-4ABE-8F0D-49496A74FBE8Q28208872-F00D6B09-2088-4157-81E0-3624B8B25A87Q28748976-FBE9DF9C-B492-40BA-8459-6E1E7B862403Q30386701-23D7C937-1FB1-4E5C-A9FE-E33AAFD2AF5CQ30410411-BEAB49DD-5F48-48BD-B4E1-C03B85E12B55Q30830619-58777F76-0F88-49AD-944A-2305E3595438Q30992754-7C98FE7B-3F38-4998-8390-B872A15E3AC0Q33239376-CC9D73D5-AD27-4F9C-8240-C3133179E84DQ33247450-ED9089BA-2A5A-4DD5-A9F7-EB6C74869E7AQ33274640-3E02A0E9-9097-4C72-8F5C-D4713ED9B2AAQ33325923-08653663-891B-49D5-81D3-D818BC61B3FEQ33344499-5681A599-3A64-4FB5-9E2F-DD841C8C3198Q33349793-EDE4F9B5-E480-455D-97B4-C20E025DEE0EQ33352680-BD1E9037-B382-4B24-9B88-A14BA07FB395Q33354070-1F686AED-1994-43CD-8265-F85F01AC31FDQ33378477-12C5E181-9454-4969-8A75-C54223E1828DQ33385995-5707154B-28BC-43F1-B3FE-548F8E868FD2Q33394563-7BDFFFF5-4024-43F0-A5E9-DB51F5ED0AF5Q33494829-322BCD89-3CAC-456C-BD59-A9C73AAA2F46Q33515034-A9991753-EAC2-4AE0-BF8A-544AB444337FQ33606936-F7A43486-73E0-44F4-9717-57B483E9A17DQ33619649-CB733D18-9301-45F4-B5DB-E725BD9BA13AQ33712891-F824B450-74FC-416C-A6B4-B7A31747F7ECQ33724256-6C2787AE-5AAA-4941-9C59-32759B3F7B61Q33724305-92A28F32-15ED-4D0E-9809-11C00C071861Q33737646-1E189BC7-1115-4A53-A2F7-34EFB99E39E4Q33747537-B73CBA11-B432-4CD0-8FB2-BAD4073813FEQ33754974-DB3CA592-506A-4178-8BE2-3B1B0473EE11Q33758570-129E3FA9-8B3D-4795-BAA4-953062F9D855Q33812154-88C209C2-B739-4CE4-9425-EC3EDE2E9E13
P2860
Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Clustered mutations in HIV-1 g ...... otoxic T lymphocyte responses.
@ast
Clustered mutations in HIV-1 g ...... otoxic T lymphocyte responses.
@en
type
label
Clustered mutations in HIV-1 g ...... otoxic T lymphocyte responses.
@ast
Clustered mutations in HIV-1 g ...... otoxic T lymphocyte responses.
@en
prefLabel
Clustered mutations in HIV-1 g ...... otoxic T lymphocyte responses.
@ast
Clustered mutations in HIV-1 g ...... otoxic T lymphocyte responses.
@en
P2093
P2860
P50
P921
P356
P1476
Clustered mutations in HIV-1 g ...... totoxic T lymphocyte responses
@en
P2093
A D Kelleher
A J McMichael
J S Sullivan
P2860
P304
P356
10.1084/JEM.193.3.375
P407
P577
2001-02-01T00:00:00Z