Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. - sprookjes - yvandenbroek - TriplyDB

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.

http://www.wikidata.org/entity/Q36471184

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Targeting Protein-Protein Interactions in the HIF System Hypoxia, Epithelial-Mesenchymal Transition, and TET-Mediated Epigenetic Changes Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia Oxygen Sensing and Homeostasis Epigenetic regulation by histone demethylases in hypoxia Role of hypoxia-inducible factors in breast cancer metastasis KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells Epigenetic determinants of metastasis Histone demethylase RBP2 is critical for breast cancer progression and metastasis.Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors.Chem-seq permits identification of genomic targets of drugs against androgen receptor regulation selected by functional phenotypic screens.Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.The multifaceted von Hippel-Lindau tumour suppressor protein.Epigenetic programming of hypoxic-ischemic encephalopathy in response to fetal hypoxia.The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer.A regulatory feedback loop between HIF-1α and PIM2 in HepG2 cells Functional regulation of hypoxia inducible factor-1α by SET9 lysine methyltransferase.Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway.Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.Meta-Analysis of Public Microarray Datasets Reveals Voltage-Gated Calcium Gene Signatures in Clinical Cancer Patients.A three-gene signature and clinical outcome in esophageal squamous cell carcinoma HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells.TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.The hypoxic tumor microenvironment: A driving force for breast cancer progression.Regulation of cell proliferation by hypoxia-inducible factors Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer.Hypoxia-regulated target genes implicated in tumor metastasis.Epigenetics, TET proteins, and hypoxia in epithelial-mesenchymal transition and tumorigenesis Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.Autophagy in breast cancer and its implications for therapy Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.KDM4B is a master regulator of the estrogen receptor signalling cascade.Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart Tubular von Hippel-Lindau knockout protects against rhabdomyolysis-induced AKI.Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma.Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.Genetic susceptibility to interstitial pulmonary fibrosis in mice induced by vanadium pentoxide (V2O5).The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.

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Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.

http://www.wikidata.org/entity/Q36471184

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P2860

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

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