The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans. - sprookjes - yvandenbroek - TriplyDB

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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Uncovering the role of p53 splice variants in human malignancy: a clinical perspective Biosensors in clinical practice: focus on oncohematology.Altered Expression of Genes in Signaling Pathways Regulating Proliferation of Hematopoietic Stem and Progenitor Cells in Mice with Subchronic Benzene Exposure Haploinsufficient tumor suppressor genes.DNA damage responses and oxidative stress in dyskeratosis congenita.MicroRNA 155 control of p53 activity is context dependent and mediated by Aicda and Socs1.Alpha-enolase is upregulated on the cell surface and responds to plasminogen activation in mice expressing a ∆133p53α mimic.Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita.Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis.Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish Gamma-Tocotrienol Modulates Radiation-Induced MicroRNA Expression in Mouse Spleen.USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis.The Pu.1 target gene Zbtb11 regulates neutrophil development through its integrase-like HHCC zinc finger.Role of long non-coding RNAs in normal and malignant hematopoiesis.DNA damage response, redox status and hematopoiesis.Cellular stress pathways in pediatric bone marrow failure syndromes: many roads lead to neutropenia.Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis.Disease-specific mutations in mature lymphoid neoplasms: recent advances.Unravelling mechanisms of p53-mediated tumour suppression.Natural course and biology of CML.The Inhibitory Effect of Ginger Extract on Ovarian Cancer Cell Line; Application of Systems Biology.Airway epithelial cell-derived insulin-like growth factor-1 triggers skewed CD8(+) T cell polarization.Li-Fraumeni syndrome: a paradigm for the understanding of hereditary cancer predisposition.p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.Increased risk for lymphoma following hemorrhagic fever with renal syndrome.Mdm2 Phosphorylation Regulates Its Stability and Has Contrasting Effects on Oncogene and Radiation-Induced Tumorigenesis.Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia.Expansion of the hematopoietic stem cell compartment is necessary but not sufficient for gain-of-function mutant p53 R248Q to accelerate lymphomagenesis.Dysfunctional diversity of p53 proteins in adult acute myeloid leukemia: projections on diagnostic workup and therapy.New monogenic disorders identify more pathways to neutropenia: from the clinic to next-generation sequencing.Proteomic analysis of JAK2V617F-induced changes identifies potential new combinatorial therapeutic approaches.Basal p53 expression is indispensable for mesenchymal stem cell integrity.Li-Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53.Cell-Cycle-Specific Function of p53 in Fanconi Anemia Hematopoietic Stem and Progenitor Cell Proliferation.Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera.Impairment of fetal hematopoietic stem cell function in the absence of Fancd2.Deconstructing networks of p53-mediated tumor suppression in vivo.

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P2860

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

http://www.wikidata.org/entity/Q36509629

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2012 nî lūn-bûn

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name

The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans.

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Alfonso Quintás-Cardama

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Guillermina Lozano

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Vinod Pant

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P2860

Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development.

Human RPS19, the gene mutated in Diamond-Blackfan anemia, encodes a ribosomal protein required for the maturation of 40S ribosomal subunits

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

Mutation of ribosomal protein RPS24 in Diamond-Blackfan anemia results in a ribosome biogenesis disorder

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

A model for p53-induced apoptosis

Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain

Ribosomal protein S17 gene (RPS17) is mutated in Diamond-Blackfan anemia

Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein

Mdm2 promotes the rapid degradation of p53

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5118-5127

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10.1182/BLOOD-2012-05-356014

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26

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